Phosphoribosyl-AMP cyclohydrolase
From Wikipedia, the free encyclopedia
In enzymology, a phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) is an enzyme that catalyzes the chemical reaction
- 1-(5-phosphoribosyl)-AMP + H2O
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4-carboxamide
Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-AMP and H2O, whereas its two products are [[1-(5-phosphoribosyl)-5-[(5-]] and [[phosphoribosylamino)methylideneamino]imidazole-4-carboxamide]].
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase. Other names in common use include PRAMP-cyclohydrolase, and phosphoribosyladenosine monophosphate cyclohydrolase. This enzyme participates in histidine metabolism.
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[edit] Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1ZPS.
[edit] References
- IUBMB entry for 3.5.4.19
- BRENDA references for 3.5.4.19 (Recommended.)
- PubMed references for 3.5.4.19
- PubMed Central references for 3.5.4.19
- Google Scholar references for 3.5.4.19
- Minson AC, Creaser EH (1969). "Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa". Biochem. J. 114: 49–56. PMID 4309307.
[edit] External links
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- The CAS registry number for this enzyme class is 37289-22-8.
[edit] Gene Ontology (GO) codes
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