Phosphopantothenoylcysteine decarboxylase
From Wikipedia, the free encyclopedia
In enzymology, a phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) is an enzyme that catalyzes the chemical reaction
- N-[(R)-4'-phosphopantothenoyl]-L-cysteine
pantotheine 4'-phosphate + CO2
Hence, this enzyme has one substrate, [[N-[(R)-4'-phosphopantothenoyl]-L-cysteine]], and two products, pantotheine 4'-phosphate and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming). Other names in common use include 4-phosphopantotheoylcysteine decarboxylase, 4-phosphopantothenoyl-L-cysteine decarboxylase, PPC-decarboxylase, and N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase. This enzyme participates in pantothenate and coa biosynthesis.
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[edit] Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1MVL, 1MVN, and 1QZU.
[edit] References
- IUBMB entry for 4.1.1.36
- BRENDA references for 4.1.1.36 (Recommended.)
- PubMed references for 4.1.1.36
- PubMed Central references for 4.1.1.36
- Google Scholar references for 4.1.1.36
- Brown GM (1958). "Requirement of cytidine triphosphate for the biosynthesis of phosphopantetheine". J. Am. Chem. Soc. 80: 3161. doi:.
- BROWN GM (1959). "The metabolism of pantothenic acid". J. Biol. Chem. 234: 370–8. PMID 13630913.
[edit] External links
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- The CAS registry number for this enzyme class is 9024-69-5.
[edit] Gene Ontology (GO) codes
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