Phosphonopyruvate hydrolase

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In enzymology, a phosphonopyruvate hydrolase (EC 3.11.1.3) is an enzyme that catalyzes the chemical reaction

3-phosphonopyruvate + H₂O $\rightleftharpoons$ pyruvate + phosphate

Thus, the two substrates of this enzyme are 3-phosphonopyruvate and H₂O, whereas its two products are pyruvate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is '. This enzyme is also called PPH'.

[edit] References

IUBMB entry for 3.11.1.3
BRENDA references for 3.11.1.3 (Recommended.)
PubMed references for 3.11.1.3
PubMed Central references for 3.11.1.3
Google Scholar references for 3.11.1.3
Ternan NG, Hamilton JT, Quinn JP (2000). "Initial in vitro characterisation of phosphonopyruvate hydrolase, a novel phosphate starvation-independent, carbon-phosphorus bond cleavage enzyme in Burkholderia cepacia Pal6". Arch. Microbiol. 173: 35–41. doi:10.1007/s002030050005. PMID 10648102.
Kulakova AN, Wisdom GB, Kulakov LA, Quinn JP (2003). "The purification and characterization of phosphonopyruvate hydrolase, a novel carbon-phosphorus bond cleavage enzyme from Variovorax sp Pal2". J. Biol. Chem. 278: 23426–31. doi:10.1074/jbc.M301871200. PMID 12697754.
Dunaway-Mariano D, Herzberg O (2006). "Structure and kinetics of phosphonopyruvate hydrolase from Variovorax sp. Pal2: new insight into the divergence of catalysis within the PEP mutase/isocitrate lyase superfamily". Biochemistry. 45: 11491–504. doi:10.1021/bi061208l. PMID 16981709.