Phosphonoacetate hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a phosphonoacetate hydrolase (EC 3.11.1.2) is an enzyme that catalyzes the chemical reaction

phosphonoacetate + H₂O acetate + phosphate

Thus, the two substrates of this enzyme are phosphonoacetate and H₂O, whereas its two products are acetate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is phosphonoacetate phosphonohydrolase. This enzyme participates in aminophosphonate metabolism. It employs one cofactor, zinc.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1EI6.

[edit] References

• IUBMB entry for 3.11.1.2
• BRENDA references for 3.11.1.2 (Recommended.)
• PubMed references for 3.11.1.2
• PubMed Central references for 3.11.1.2
• Google Scholar references for 3.11.1.2
• McGrath JW, Wisdom GB, McMullan G, Larkin MJ, Quinn JP (1995). "The purification and properties of phosphonoacetate hydrolase, a novel carbon-phosphorus bond-cleavage enzyme from Pseudomonas fluorescens 23F". Eur. J. Biochem. 234: 225–30. doi:10.1111/j.1432-1033.1995.225_c.x. PMID 8529644. 

[edit] External links

The CAS registry number for this enzyme class is 153570-68-4.

• IUBMB entry for 3.11.1.2

• KEGG entry for 3.11.1.2

• BRENDA entry for 3.11.1.2

• NiceZyme view of 3.11.1.2

• EC2PDB: PDB structures for 3.11.1.2

• PRIAM entry for 3.11.1.2

• PUMA2 entry for 3.11.1.2

• IntEnz: Integrated Enzyme entry for 3.11.1.2

• MetaCyc entry for 3.11.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047400: phosphonoacetate hydrolase

• AMIGO entry for GO code 0047400: phosphonoacetate hydrolase