Phosphonoacetaldehyde hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a phosphonoacetaldehyde hydrolase (EC 3.11.1.1) is an enzyme that catalyzes the chemical reaction

phosphonoacetaldehyde + H₂O $\rightleftharpoons$ acetaldehyde + phosphate

Thus, the two substrates of this enzyme are phosphonoacetaldehyde and H₂O, whereas its two products are acetaldehyde and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is 2-oxoethylphosphonate phosphonohydrolase. Other names in common use include phosphonatase, and 2-phosphonoacetylaldehyde phosphonohydrolase. This enzyme participates in aminophosphonate metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1SWV and 1SWW.

[edit] References

IUBMB entry for 3.11.1.1
BRENDA references for 3.11.1.1 (Recommended.)
PubMed references for 3.11.1.1
PubMed Central references for 3.11.1.1
Google Scholar references for 3.11.1.1
La Nauze JM, Rosenberg H (1968). "The identification of 2-phosphonoacetaldehyde as an intermediate in the degradation of 2-aminoethylphosphonate by Bacillus cereus". Biochim. Biophys. Acta. 165: 438–47. PMID 4982500.
La Nauze JM, Rosenberg H, Shaw DC (1970). "The enzymic cleavage of the carbon-phosphorus bond: purification and properties of phosphonatase". Biochim. Biophys. Acta. 212: 332–50. PMID 4989158.
La Nauze JM, Coggins JR, Dixon HB (1977). "Aldolase-like imine formation in the mechanism of action of phosphonoacetaldehyde hydrolase". Biochem. J. 165: 409–11. PMID 200222.
Olsen DB, Hepburn TW, Moos M, Mariano PS, Dunaway-Mariano D (1988). "Investigation of the Bacillus cereus phosphonoacetaldehyde hydrolase. Evidence for a Schiff base mechanism and sequence analysis of an active-site peptide containing the catalytic lysine residue". Biochemistry. 27: 2229–34. doi:10.1021/bi00406a063. PMID 3132206.
Martin BM, Dunaway-Mariano D (1998). "Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis". Biochemistry. 37: 9305–15. doi:10.1021/bi972677d. PMID 9649311.