Phosphonate-transporting ATPase

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In enzymology, a phosphonate-transporting ATPase (EC 3.6.3.28) is an enzyme that catalyzes the chemical reaction

ATP + H₂O + phosphonateout $\rightleftharpoons$ ADP + phosphate + phosphonatein

The 3 substrates of this enzyme are ATP, H₂O, and phosphonate, whereas its 3 products are ADP, phosphate, and phosphonate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (phosphonate-transporting).

[edit] References

IUBMB entry for 3.6.3.28
BRENDA references for 3.6.3.28 (Recommended.)
PubMed references for 3.6.3.28
PubMed Central references for 3.6.3.28
Google Scholar references for 3.6.3.28
Wanner BL, Metcalf WW (1992). "Molecular genetic studies of a 10.9-kb operon in Escherichia coli for phosphonate uptake and biodegradation". FEMS. Microbiol. Lett. 79: 133–9. PMID 1335942.
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases". Res. Microbiol. 146: 271–8. PMID 7569321.
Saier MH Jr (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol. 40: 81–136. PMID 9889977.
Griffiths JK and Sansom CE. "The Transporter Factsbook, Academic Press, San Diego, 1998".