Phosphoinositide 5-phosphatase

From Wikipedia, the free encyclopedia

In enzymology, a phosphoinositide 5-phosphatase (EC 3.1.3.36) is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

Thus, the two substrates of this enzyme are 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate and H₂O, whereas its two products are 1-phosphatidyl-1D-myo-inositol 4-phosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase. Other names in common use include type II inositol polyphosphate 5-phosphatase, triphosphoinositide phosphatase, IP3 phosphatase, PtdIns(4,5)P2 phosphatase, triphosphoinositide phosphomonoesterase, diphosphoinositide phosphatase, inositol 1,4,5-triphosphate 5-phosphomonoesterase, inositol triphosphate 5-phosphomonoesterase, phosphatidylinositol-bisphosphatase, phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase, phosphatidylinositol 4,5-bisphosphate phosphatase, polyphosphoinositol lipid 5-phosphatase, and phosphatidyl-inositol-bisphosphate phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1UFW, 1W80, 2DNR, and 2QV2.

[edit] References

• IUBMB entry for 3.1.3.36
• BRENDA references for 3.1.3.36 (Recommended.)
• PubMed references for 3.1.3.36
• PubMed Central references for 3.1.3.36
• Google Scholar references for 3.1.3.36
• Dawson RM, Thompson W (1964). "The triphosphoinositide phosphomonoesterase of brain tissue". Biochem. J. 91: 244–50. PMID 4284485. 
• Roach PD, Palmer FB (1981). "Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate phosphatase". Biochim. Biophys. Acta. 661: 323–33. PMID 6271223. 
• Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.

[edit] External links

The CAS registry number for this enzyme class is 9036-01-5.

• IUBMB entry for 3.1.3.36

• KEGG entry for 3.1.3.36

• BRENDA entry for 3.1.3.36

• NiceZyme view of 3.1.3.36

• EC2PDB: PDB structures for 3.1.3.36

• PRIAM entry for 3.1.3.36

• PUMA2 entry for 3.1.3.36

• IntEnz: Integrated Enzyme entry for 3.1.3.36

• MetaCyc entry for 3.1.3.36

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004439: phosphoinositide 5-phosphatase

• AMIGO entry for GO code 0004439: phosphoinositide 5-phosphatase