Phosphogluconate dehydrogenase (decarboxylating)

From Wikipedia, the free encyclopedia

In enzymology, a phosphogluconate dehydrogenase (decarboxylating) (EC 1.1.1.44) is an enzyme that catalyzes the chemical reaction

6-phospho-D-gluconate + NADP⁺ $\rightleftharpoons$ D-ribulose 5-phosphate + CO₂ + NADPH

Thus, the two substrates of this enzyme are 6-phospho-D-gluconate and NADP⁺, whereas its 3 products are D-ribulose 5-phosphate, CO₂, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating). Other names in common use include phosphogluconic acid dehydrogenase, 6-phosphogluconic dehydrogenase, 6-phosphogluconic carboxylase, 6-phosphogluconate dehydrogenase (decarboxylating), and 6-phospho-D-gluconate dehydrogenase. This enzyme participates in pentose phosphate pathway. It employs one cofactor, manganese.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1PGJ, 1PGN, 1PGO, 1PGP, 1PGQ, 2IYO, 2IYP, 2IZ0, 2IZ1, 2P4Q, and 2PGD.

[edit] References

IUBMB entry for 1.1.1.44
BRENDA references for 1.1.1.44 (Recommended.)
PubMed references for 1.1.1.44
PubMed Central references for 1.1.1.44
Google Scholar references for 1.1.1.44
DICKENS F, GLOCK GE (1951). "Direct oxidation of glucose-6-phosphate, 6-phosphogluconate and pentose-5-phosphates by enzymes of animal origin". Biochem. J. 50: 81–95. PMID 14904376.
Bonsignore A and Horecker BL (1961). "Purification and properties of beta-L-hydroxy acid dehydrogenase II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis". J. Biol. Chem. 236: 2975–2980.
Scott DBM and Cohen SS (1953). "The oxidative pathway of carbohydrate metabolism in Escherichia coli. 1. The isolation and properties of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase". Biochem. J. 55: 23–33.
Scott DBM and Cohen SS (1957). "The oxidative pathway of carbohydrate metabolism in Escherichia coli. 5. Isolation and identification of ribulose phosphate produced from 6-phosphogluconate by the dehydrogenase of E. coli". Biochem. J. 65: 686–689.