Phosphoenolpyruvate mutase

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In enzymology, a phosphoenolpyruvate mutase (EC 5.4.2.9) is an enzyme that catalyzes the chemical reaction

phosphoenolpyruvate $\rightleftharpoons$ 3-phosphonopyruvate

Hence, this enzyme has one substrate, phosphoenolpyruvate, and one product, 3-phosphonopyruvate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is phosphoenolpyruvate 2,3-phosphonomutase. Other names in common use include phosphoenolpyruvate-phosphonopyruvate phosphomutase, PEP phosphomutase, phosphoenolpyruvate phosphomutase, PEPPM, and PEP phosphomutase. This enzyme participates in aminophosphonate metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1M1B, 1PYM, 1S2T, 1S2U, 1S2V, and 1S2W.

[edit] References

IUBMB entry for 5.4.2.9
BRENDA references for 5.4.2.9 (Recommended.)
PubMed references for 5.4.2.9
PubMed Central references for 5.4.2.9
Google Scholar references for 5.4.2.9
Bowman E, McQueney M, Barry RJ and Dunaway-Mariano D (1988). "Catalysis and thermodynamics of the phosphoenolpyruvate phosphonopyruvate rearrangement - entry into the phosphonate class of naturally-occurring organo-phosphorus compounds". J. Am. Chem. Soc. 110: 5575–5576. doi:10.1021/ja00224a054.
Hidaka T, Imai S, Hara O, Anzai H, Murakami T, Nagaoka K, Seto H (1990). "Carboxyphosphonoenolpyruvate phosphonomutase, a novel enzyme catalyzing C-P bond formation". J. Bacteriol. 172: 3066–72. PMID 2160937.
Seidel HM, Freeman S, Seto H, Knowles JR (1988). "Phosphonate biosynthesis: isolation of the enzyme responsible for the formation of a carbon-phosphorus bond". Nature. 335: 457–8. doi:10.1038/335457a0. PMID 3138545.