Phosphoenolpyruvate-protein phosphotransferase

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In enzymology, a phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) is an enzyme that catalyzes the chemical reaction

phosphoenolpyruvate + protein histidine pyruvate + protein Npi-phospho-L-histidine

Thus, the two substrates of this enzyme are phosphoenolpyruvate and protein histidine, whereas its two products are pyruvate and protein Npi-phospho-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a nitrogenous group as acceptor. The systematic name of this enzyme class is phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase. Other names in common use include phosphoenolpyruvate sugar phosphotransferase enzyme I, phosphopyruvate-protein factor phosphotransferase, phosphopyruvate-protein phosphotransferase, sugar-PEP phosphotransferase enzyme I, and phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase. This enzyme participates in phosphotransferase system (pts).

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1EZA, 1EZB, 1EZC, 1EZD, 1ZYM, 2EZA, 2EZB, 2EZC, 2HRO, 2HWG, 3EZA, 3EZB, and 3EZE.

[edit] References

• IUBMB entry for 2.7.3.9
• BRENDA references for 2.7.3.9 (Recommended.)
• PubMed references for 2.7.3.9
• PubMed Central references for 2.7.3.9
• Google Scholar references for 2.7.3.9
• "The bacterial phosphoenolpyruvate: sugar phosphotransferase system" (1976). Biochim. Biophys. Acta. 457: 213–57. PMID 187249. 

[edit] External links

The CAS registry number for this enzyme class is 37278-17-4.

• IUBMB entry for 2.7.3.9

• KEGG entry for 2.7.3.9

• BRENDA entry for 2.7.3.9

• NiceZyme view of 2.7.3.9

• EC2PDB: PDB structures for 2.7.3.9

• PRIAM entry for 2.7.3.9

• PUMA2 entry for 2.7.3.9

• IntEnz: Integrated Enzyme entry for 2.7.3.9

• MetaCyc entry for 2.7.3.9

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008965: phosphoenolpyruvate-protein phosphotransferase

• AMIGO entry for GO code 0008965: phosphoenolpyruvate-protein phosphotransferase