Phosphoadenylylsulfatase

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In enzymology, a phosphoadenylylsulfatase (EC 3.6.2.2) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + H₂O adenosine 3',5'-bisphosphate + sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and H₂O, whereas its two products are adenosine 3',5'-bisphosphate and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in sulfonyl-containing anhydrides. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate sulfohydrolase. Other names in common use include 3-phosphoadenylyl sulfatase, 3-phosphoadenosine 5-phosphosulfate sulfatase, PAPS sulfatase, and 3'-phosphoadenylylsulfate sulfohydrolase. This enzyme participates in sulfur metabolism. It employs one cofactor, manganese.

[edit] References

• IUBMB entry for 3.6.2.2
• BRENDA references for 3.6.2.2 (Recommended.)
• PubMed references for 3.6.2.2
• PubMed Central references for 3.6.2.2
• Google Scholar references for 3.6.2.2
• BALASUBRAMANIAN AS, BACHHAWAT BK (1962). "Enzymic degradation of active sulphate". Biochim. Biophys. Acta. 59: 389–97. doi:10.1016/0006-3002(62)90188-9. PMID 13864264. 

[edit] External links

The CAS registry number for this enzyme class is 37289-37-5.

• IUBMB entry for 3.6.2.2

• KEGG entry for 3.6.2.2

• BRENDA entry for 3.6.2.2

• NiceZyme view of 3.6.2.2

• EC2PDB: PDB structures for 3.6.2.2

• PRIAM entry for 3.6.2.2

• PUMA2 entry for 3.6.2.2

• IntEnz: Integrated Enzyme entry for 3.6.2.2

• MetaCyc entry for 3.6.2.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050186: phosphoadenylylsulfatase

• AMIGO entry for GO code 0050186: phosphoadenylylsulfatase