Phosphoacetylglucosamine mutase

From Wikipedia, the free encyclopedia

In enzymology, a phosphoacetylglucosamine mutase (EC 5.4.2.3) is an enzyme that catalyzes the chemical reaction

N-acetyl-alpha-D-glucosamine 1-phosphate $\rightleftharpoons$ N-acetyl-D-glucosamine 6-phosphate

Hence, this enzyme has one substrate, N-acetyl-alpha-D-glucosamine 1-phosphate, and one product, N-acetyl-D-glucosamine 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is N-acetyl-alpha-D-glucosamine 1,6-phosphomutase. Other names in common use include acetylglucosamine phosphomutase, acetylglucosamine phosphomutase, acetylaminodeoxyglucose phosphomutase, phospho-N-acetylglucosamine mutase, and N-acetyl-D-glucosamine 1,6-phosphomutase. This enzyme participates in aminosugars metabolism. This enzyme has at least one effector, N-Acetyl-D-glucosamine 1,6-bisphosphate.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1WJW, 2DKA, 2DKC, and 2DKD.

[edit] References

IUBMB entry for 5.4.2.3
BRENDA references for 5.4.2.3 (Recommended.)
PubMed references for 5.4.2.3
PubMed Central references for 5.4.2.3
Google Scholar references for 5.4.2.3
Carlson DM (1966). "Phosphoacetylglucosamine mutase from pig submaxillary gland". Methods Enzymol. 8: 179–182.
LELOIR LF, CARDINI CE (1956). "Enzymes acting on glucosamine phosphate". Biochim. Biophys. Acta. 20: 33–42. doi:10.1016/0006-3002(56)90259-1. PMID 13315346.
Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p. 407-477.
Reissig JL and Leloir LF (1966). "Phosphoacetylglucosamine mutase from Neurospora". Methods Enzymol. 8: 175–178.