Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

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In enzymology, a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) is an enzyme that catalyzes the chemical reaction

phosphatidylinositol 3,4,5-trisphosphate + H₂O $\rightleftharpoons$ phosphatidylinositol 4,5-bisphosphate + phosphate

Thus, the two substrates of this enzyme are phosphatidylinositol 3,4,5-trisphosphate and H₂O, whereas its two products are phosphatidylinositol 4,5-bisphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase. Other names in common use include PTEN, MMAC1, and phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. This enzyme participates in 10 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, p53 signaling pathway, focal adhesion, tight junction, endometrial cancer, glioma, prostate cancer, melanoma, and small cell lung cancer. It employs one cofactor, magnesium.

[edit] References

IUBMB entry for 3.1.3.67
BRENDA references for 3.1.3.67 (Recommended.)
PubMed references for 3.1.3.67
PubMed Central references for 3.1.3.67
Google Scholar references for 3.1.3.67
Kabuyama Y, Nakatsu N, Homma Y, Fukui Y (1996). "Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus". Eur. J. Biochem. 238: 350–6. doi:10.1111/j.1432-1033.1996.0350z.x. PMID 8681945.
Maehama T, Dixon JE (1998). "The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate". J. Biol. Chem. 273: 13375–8. doi:10.1074/jbc.273.22.13375. PMID 9593664.