Phosphatidylethanolamine N-methyltransferase

From Wikipedia, the free encyclopedia

Phosphatidylethanolamine N-methyltransferase
Identifiers
Symbol	PEMT
Entrez	10400
HUGO	8830
RefSeq	NM_007169
Other data
EC number	2.1.1.17
Locus	Chr. 17 p11.2

In enzymology, a phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + phosphatidylethanolamine S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine

Thus, the two substrates of this enzyme are S-adenosyl methionine and phosphatidylethanolamine, whereas its two products are S-adenosylhomocysteine and phosphatidyl-N-methylethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase. Other names in common use include PEMT, LMTase, lipid methyl transferase, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine-N-methylase, and phosphatidylethanolamine-S-adenosylmethionine methyltransferase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism.

[edit] References

• IUBMB entry for 2.1.1.17
• BRENDA references for 2.1.1.17 (Recommended.)
• PubMed references for 2.1.1.17
• PubMed Central references for 2.1.1.17
• Google Scholar references for 2.1.1.17
• Hirata F, Viveros OH, Diliberto EJ Jr, Axelrod J (1978). "Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine". Proc. Natl. Acad. Sci. U. S. A. 75: 1718–21. doi:10.1073/pnas.75.4.1718. PMID 25437. 
• Morgan TE (1969). "Isolation and characterization of lipid N-methylrtansferase from dog lung". Biochim. Biophys. Acta. 178: 21–34. PMID 5773456. 
• Schneider WJ, Vance DE (1979). "Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities". J. Biol. Chem. 254: 3886–91. PMID 438165. 

[edit] External links

The CAS registry number for this enzyme class is 37256-91-0.

• IUBMB entry for 2.1.1.17

• KEGG entry for 2.1.1.17

• BRENDA entry for 2.1.1.17

• NiceZyme view of 2.1.1.17

• EC2PDB: PDB structures for 2.1.1.17

• PRIAM entry for 2.1.1.17

• PUMA2 entry for 2.1.1.17

• IntEnz: Integrated Enzyme entry for 2.1.1.17

• MetaCyc entry for 2.1.1.17

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004608: phosphatidylethanolamine N-methyltransferase

• AMIGO entry for GO code 0004608: phosphatidylethanolamine N-methyltransferase

v • d • e Transferase: one carbon transferases (EC 2.1) 2.1.1 - Methyltransferases N-methyltransferase: Histamine N-methyltransferase - Phenylethanolamine N-methyltransferase - Tryptamine N-methyltransferase - Phosphatidylethanolamine N-methyltransferase O-methyltransferase: 5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase - Catechol-O-methyl transferase homocysteine methyltransferase: Betaine-homocysteine methyltransferase - Homocysteine methyltransferase - 5-Methyltetrahydrofolate-homocysteine methyltransferase Other: Phosphatidyl ethanolamine methyltransferase - DNMT3B - Histone methyltransferase - Thymidylate synthase - DNA methyltransferase 2.1.2 - Hydroxy methyl-, Formyl- and Related Transferases Serine hydroxymethyltransferase - Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase - Glutamate formimidoyltransferase - Aminomethyltransferase 2.1.3 - Carboxy- and Carbamoyl transferases Ornithine transcarbamylase 2.1.4 - Amidino transferases Arginine:glycine amidinotransferase