Phosphatidylcholine synthase

From Wikipedia, the free encyclopedia

In enzymology, a phosphatidylcholine synthase (EC 2.7.8.24) is an enzyme that catalyzes the chemical reaction

CDP-diacylglycerol + choline CMP + phosphatidylcholine

Thus, the two substrates of this enzyme are CDP-diacylglycerol and choline, whereas its two products are CMP and phosphatidylcholine.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-diacylglycerol:choline O-phosphatidyltransferase. This enzyme is also called CDP-diglyceride-choline O-phosphatidyltransferase. This enzyme participates in glycerophospholipid metabolism.

[edit] References

• IUBMB entry for 2.7.8.24
• BRENDA references for 2.7.8.24 (Recommended.)
• PubMed references for 2.7.8.24
• PubMed Central references for 2.7.8.24
• Google Scholar references for 2.7.8.24
• de Rudder KE, Sohlenkamp C, Geiger O (1999). "Plant-exuded choline is used for rhizobial membrane lipid biosynthesis by phosphatidylcholine synthase". J. Biol. Chem. 274: 20011–6. doi:10.1074/jbc.274.28.20011. PMID 10391951. 
• Sohlenkamp C, de Rudder KE, Rohrs V, Lopez-Lara IM, Geiger O (2000). "Cloning and characterization of the gene for phosphatidylcholine synthase". J. Biol. Chem. 275: 18919–25. doi:10.1074/jbc.M000844200. PMID 10858449. 

[edit] External links

The CAS registry number for this enzyme class is 243666-86-6.

• IUBMB entry for 2.7.8.24

• KEGG entry for 2.7.8.24

• BRENDA entry for 2.7.8.24

• NiceZyme view of 2.7.8.24

• EC2PDB: PDB structures for 2.7.8.24

• PRIAM entry for 2.7.8.24

• PUMA2 entry for 2.7.8.24

• IntEnz: Integrated Enzyme entry for 2.7.8.24

• MetaCyc entry for 2.7.8.24

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050520: phosphatidylcholine synthase

• AMIGO entry for GO code 0050520: phosphatidylcholine synthase