Phosphatidylcholine 12-monooxygenase

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In enzymology, a phosphatidylcholine 12-monooxygenase (EC 1.14.13.26) is an enzyme that catalyzes the chemical reaction

1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NADH + H⁺ + O₂ $\rightleftharpoons$ 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + NAD⁺ + H₂O

The 4 substrates of this enzyme are 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine, NADH, H⁺, and O₂, whereas its 3 products are [[1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine]], NAD⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating). Other names in common use include ricinoleic acid synthase, oleate Delta12-hydroxylase, and oleate Delta12-monooxygenase.

[edit] References

IUBMB entry for 1.14.13.26
BRENDA references for 1.14.13.26 (Recommended.)
PubMed references for 1.14.13.26
PubMed Central references for 1.14.13.26
Google Scholar references for 1.14.13.26
Galliard T, Stumpf PK (1966). "Fat metabolism in higher plants. 30. Enzymatic synthesis of ricinoleic acid by a microsomal preparation from developing Ricinus communis seeds". J. Biol. Chem. 241: 5806–12. PMID 4289003.
Moreau RA and Stumpf PK (1981). "Recent studies of the enzymic-synthesis of ricinoleic acid by developing castor beans". Plant Physiol. 67: 672–676.