Phosphatidic acid phosphatase 2c

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Phosphatidic acid phosphatase type 2C
Identifiers
Symbol(s) PPAP2C; LPP2; PAP-2c; PAP2-g
External IDs OMIM: 607126 MGI: 1354945 HomoloGene: 2752
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8612 50784
Ensembl ENSG00000141934 ENSMUSG00000052151
Uniprot O43688 Q5U4G4
Refseq NM_003712 (mRNA)
NP_003703 (protein)		 NM_015817 (mRNA)
NP_056632 (protein)
Location Chr 19: 0.23 - 0.24 Mb Chr 10: 78.93 - 78.94 Mb
Pubmed search [1] [2]

Phosphatidic acid phosphatase type 2C, also known as PPAP2C, is a human gene.[1]

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C.

[edit] Further reading

  • Nanjundan M, Possmayer F (2003). "Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase.". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L1–23. doi:10.1152/ajplung.00029.2002. PMID 12471011. 
  • Morris KE, Schang LM, Brindley DN (2006). "Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts.". J. Biol. Chem. 281 (14): 9297–306. doi:10.1074/jbc.M511710200. PMID 16467304. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zhang N, Sundberg JP, Gridley T (2000). "Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile.". Genesis 27 (4): 137–40. PMID 10992322. 
  • Roberts R, Sciorra VA, Morris AJ (1998). "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.". J. Biol. Chem. 273 (34): 22059–67. PMID 9705349. 
  • Hooks SB, Ragan SP, Lynch KR (1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform.". FEBS Lett. 427 (2): 188–92. PMID 9607309. 
  • Leung DW, Tompkins CK, White T (1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.". DNA Cell Biol. 17 (4): 377–85. PMID 9570154. 
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