Phosphatidate cytidylyltransferase

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In enzymology, a phosphatidate cytidylyltransferase (EC 2.7.7.41) is an enzyme that catalyzes the chemical reaction

CTP + phosphatidate $\rightleftharpoons$ diphosphate + CDP-diacylglycerol

Thus, the two substrates of this enzyme are CTP and phosphatidate, whereas its two products are diphosphate and CDP-diacylglycerol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:phosphatidate cytidylyltransferase. Other names in common use include CDP diglyceride pyrophosphorylase, CDP-diacylglycerol synthase, CDP-diacylglyceride synthetase, cytidine diphosphoglyceride pyrophosphorylase, phosphatidate cytidyltransferase, phosphatidic acid cytidylyltransferase, CTP:1,2-diacylglycerophosphate-cytidyl transferase, CTP-diacylglycerol synthetase, DAG synthetase, and CDP-DG. This enzyme participates in glycerophospholipid metabolism and phosphatidylinositol signaling system.

[edit] References

IUBMB entry for 2.7.7.41
BRENDA references for 2.7.7.41 (Recommended.)
PubMed references for 2.7.7.41
PubMed Central references for 2.7.7.41
Google Scholar references for 2.7.7.41
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Petzold GL, Agranoff BW (1967). "The biosynthesis of cytidine diphosphate diglyceride by embryonic chick brain". J. Biol. Chem. 242: 1187–91. PMID 6067194.