Phosducin family
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| Phosducin (yellow) - Transducin beta-gamma complex | ||
| Identifiers | ||
|---|---|---|
| Symbol | Phosducin | |
| Pfam | PF02114 | |
| InterPro | IPR001200 | |
| SCOP | 1b9y | |
| OPM family | 139 | |
| OPM protein | 1b9x | |
| Available PDB structures: | ||
The outer and inner segments of vertebrate rod photoreceptor cells contain phosducin, a soluble phosphoprotein that complexes with the beta/gamma-subunits of the GTP-binding protein, transducin. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of phosducin by protein kinase A[1]. The protein is thought to participate in the regulation of visual phototransduction or in the integration of photo-receptor metabolism. Similar proteins have been isolated from the pineal gland and it is believed that the functional role of the protein is the same in both retina and pineal gland[2].
[edit] Human proteins containing this domain
PDC; PDCL2; PDCL3; VIAF1;
[edit] References
- ^ Craft CM, Lee RH, Fowler A, Lolley RN, McGinnis JF (1990). "Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells". J. Biol. Chem. 265 (26): 15867–15873. PMID 2203790.
- ^ Takagi T, Abe T, Nakabayashi H, Tamada H, Sakuragi S, Yamaki K, Shinohara T (1990). "Analysis of the human, bovine and r at 33-kDa proteins and cDNA in retina and pineal gland". Gene 91 (2): 209–215. doi:. PMID 2210381.
This article includes text from the public domain Pfam and InterPro IPR001200
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