PHLDA1

From Wikipedia, the free encyclopedia


Pleckstrin homology-like domain, family A, member 1
Identifiers
Symbol(s) PHLDA1; DT1P1B11; MGC131738; PHRIP; TDAG51
External IDs OMIM: 605335 MGI: 1096880 HomoloGene: 7203
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 22822 21664
Ensembl ENSG00000139289 ENSMUSG00000020205
Uniprot Q8WV24 Q62392
Refseq NM_007350 (mRNA)
NP_031376 (protein)		 NM_009344 (mRNA)
NP_033370 (protein)
Location Chr 12: 74.71 - 74.71 Mb Chr 10: 110.91 - 110.91 Mb
Pubmed search [1] [2]

Pleckstrin homology-like domain, family A, member 1, also known as PHLDA1, is a human gene.[1]

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.[1]

[edit] References

  1. ^ a b Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1.

[edit] Further reading

  • Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method.". Genomics 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904. 
  • Kuske MD, Johnson JP (2000). "Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping.". Cytogenet. Cell Genet. 89 (1-2): 1. PMID 10894922. 
  • Hinz T, Flindt S, Marx A, et al. (2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product.". Cell. Signal. 13 (5): 345–52. PMID 11369516. 
  • Neef R, Kuske MA, Pröls E, Johnson JP (2002). "Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation.". Cancer Res. 62 (20): 5920–9. PMID 12384558. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hossain GS, van Thienen JV, Werstuck GH, et al. (2003). "TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia.". J. Biol. Chem. 278 (32): 30317–27. doi:10.1074/jbc.M212897200. PMID 12738777. 
  • Oberg HH, Sipos B, Kalthoff H, et al. (2005). "Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells.". Cell Death Differ. 11 (6): 674–84. doi:10.1038/sj.cdd.4401407. PMID 15002043. 
  • Toyoshima Y, Karas M, Yakar S, et al. (2004). "TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival.". J. Biol. Chem. 279 (24): 25898–904. doi:10.1074/jbc.M400661200. PMID 15037619. 
  • Meier-Noorden M, Flindt S, Kalinke U, Hinz T (2004). "A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation.". Gene 338 (2): 197–207. doi:10.1016/j.gene.2004.05.006. PMID 15315823. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
 This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it.