Philippa Marrack

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Philippa "Pippa" Marrack

Born	England
Residence	Colorado, United States
Alma mater	Cambridge University
Doctoral advisor	Alan Munro
Known for	T cells, autoimmune disease

Philippa "Pippa" Marrack is a biologist, known for her research into T cells and autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome. She collaborates with her husband, John W. Kappler.

1 Biography
2 Significant papers
3 Awards
4 Notes
5 Further reading
6 External links

[edit] Biography

Marrack was born in England, and completed both undergraduate and Ph.D. work at Cambridge University, New Hall. During her Ph.D., she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to work on T cells. She then did a postdoc with Richard Dutton at the University of California, San Diego.

Her first faculty position was with the University of Rochester, followed by the National Jewish Medical and Research Center, Denver, Colorado and the University of Colorado.

[edit] Significant papers

J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," Cell, v.49, n.2, pp. 273-80 (1987)
P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," Science, v.248 (4956), pp. 705-11 (1990).
J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," Nature, 332 (6159): pp. 35-40 (1988).
J. White, et al (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," Cell, v.56, n.1, pp. 27-35 (1989).

[edit] Awards

1986 - Appointed Investigator, Howard Hughes Medical Institute
1987 - Fellow (elected), Royal Society
1989 - Elected member, National Academy of Sciences
1990 - Royal Society Wellcome Foundation Prize
1993 - Paul Ehrlich and Ludwig Darmstaedter Prize
1994/95 - Louisa Gross Horwitz Prize
2003 - Lifetime Achievement Award, American Association of Immunologists^[1]^[2]
2004 - L'Oreal UNESCO Women in Science Award
2005 - Pearl Meister Greengard Prize^[3]
Rabbi Shai Shackner Prize (University of Jerusalem)