PHF21A

From Wikipedia, the free encyclopedia

PHD finger protein 21A

Identifiers

PHF21A; BHC80; BM-006; KIAA1696

External IDs

Gene ontology
Molecular Function:	• chromatin binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• histone deacetylase complex • nucleus
Biological Process:	• suckling behavior • transcription • regulation of transcription, DNA-dependent • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_016621 (mRNA)
NP_057705 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 11: 45.91 - 46.1 Mb

n/a

Pubmed search

[1]

n/a

PHD finger protein 21A, also known as PHF21A, is a human gene.^[1]

BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PHF21A PHD finger protein 21A.

[edit] Further reading

Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347-55. PMID 11214970.
Hakimi MA, Bochar DA, Chenoweth J, et al. (2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420-5. doi:10.1073/pnas.112008599. PMID 12032298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hakimi MA, Dong Y, Lane WS, et al. (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.". J. Biol. Chem. 278 (9): 7234-9. doi:10.1074/jbc.M208992200. PMID 12493763.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Iwase S, Januma A, Miyamoto K, et al. (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.". Biochem. Biophys. Res. Commun. 322 (2): 601-8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Shi YJ, Matson C, Lan F, et al. (2005). "Regulation of LSD1 histone demethylase activity by its associated factors.". Mol. Cell 19 (6): 857-64. doi:10.1016/j.molcel.2005.08.027. PMID 16140033.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Hailesellasse Sene K, Porter CJ, Palidwor G, et al. (2007). "Gene function in early mouse embryonic stem cell differentiation.". BMC Genomics 8: 85. doi:10.1186/1471-2164-8-85. PMID 17394647.