PHF1

From Wikipedia, the free encyclopedia

PHD finger protein 1

Identifiers

PHF1; PHF2

External IDs

OMIM: 602881 MGI: 98647 HomoloGene: 7567

Gene ontology
Molecular Function:	• nucleic acid binding • transcription factor activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002636 (mRNA)
NP_002627 (protein)

XM_994575 (mRNA)
XP_999669 (protein)

Location

Chr 6: 33.49 - 33.49 Mb

Chr 17: 26.66 - 26.67 Mb

Pubmed search

[1]

[2]

PHD finger protein 1, also known as PHF1, is a human gene.^[1]

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PHF1 PHD finger protein 1.

[edit] Further reading

Cao R, Wang H, He J, et al. (2008). "Role of hPHF1 in H3K27 methylation and Hox gene silencing.". Mol. Cell. Biol. 28 (5): 1862-72. doi:10.1128/MCB.01589-07. PMID 18086877.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
O'Connell S, Wang L, Robert S, et al. (2001). "Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein.". J. Biol. Chem. 276 (46): 43065-73. doi:10.1074/jbc.M104294200. PMID 11571280.
Coulson M, Robert S, Eyre HJ, Saint R (1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster.". Genomics 48 (3): 381-3. doi:10.1006/geno.1997.5201. PMID 9545646.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.