Phenylpyruvate tautomerase

From Wikipedia, the free encyclopedia

In enzymology, a phenylpyruvate tautomerase (EC 5.3.2.1) is an enzyme that catalyzes the chemical reaction

keto-phenylpyruvate enol-phenylpyruvate

Hence, this enzyme has one substrate, keto-phenylpyruvate, and one product, enol-phenylpyruvate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting keto- and enol-groups. The systematic name of this enzyme class is phenylpyruvate keto---enol-isomerase. This enzyme is also called phenylpyruvic keto-enol isomerase. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GYJ, 1GYX, 1GYY, 2GDG, 2OOH, 2OOW, and 2OOZ.

[edit] References

• IUBMB entry for 5.3.2.1
• BRENDA references for 5.3.2.1 (Recommended.)
• PubMed references for 5.3.2.1
• PubMed Central references for 5.3.2.1
• Google Scholar references for 5.3.2.1
• Blasi F, Fragomele F, Covelli I (1969). "Thyroidal phenylpyruvate tautomerase. Isolation and characterization". J. Biol. Chem. 244: 4864–70. PMID 5824560. 
• Knox WE (1955). "p-Hydroxyphenylpyruvate enol-keto tautomerase". Methods Enzymol. 2: 289–295. 
• KNOX WE, PITT BM (1957). "Enzymic catalysis of the keto-enol tautomerization of phenylpyruvic acids". J. Biol. Chem. 225: 675–88. PMID 13416270. 

[edit] External links

The CAS registry number for this enzyme class is 9023-54-5.

• IUBMB entry for 5.3.2.1

• KEGG entry for 5.3.2.1

• BRENDA entry for 5.3.2.1

• NiceZyme view of 5.3.2.1

• EC2PDB: PDB structures for 5.3.2.1

• PRIAM entry for 5.3.2.1

• PUMA2 entry for 5.3.2.1

• IntEnz: Integrated Enzyme entry for 5.3.2.1

• MetaCyc entry for 5.3.2.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050178: phenylpyruvate tautomerase

• AMIGO entry for GO code 0050178: phenylpyruvate tautomerase