Phenylglyoxylate dehydrogenase (acylating)

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In enzymology, a phenylglyoxylate dehydrogenase (acylating) (EC 1.2.1.58) is an enzyme that catalyzes the chemical reaction

phenylglyoxylate + NAD⁺ + CoA-SH benzoyl-S-CoA + CO₂ + NADH

The 3 substrates of this enzyme are phenylglyoxylate, NAD⁺, and CoA-SH, whereas its 3 products are benzoyl-S-CoA, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phenylglyoxylate:NAD+ oxidoreductase. It has 3 cofactors: FAD, Thiamin diphosphate, and Iron-sulfur.

[edit] References

• IUBMB entry for 1.2.1.58
• BRENDA references for 1.2.1.58 (Recommended.)
• PubMed references for 1.2.1.58
• PubMed Central references for 1.2.1.58
• Google Scholar references for 1.2.1.58
• Hirsch W, Schagger H, Fuchs G (1998). "Phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating), a new enzyme of anaerobic phenylalanine metabolism in the denitrifying bacterium Azoarcus evansii". Eur. J. Biochem. 251: 907–15. PMID 9490067. 

[edit] External links

The CAS registry number for this enzyme class is 205510-78-7.

• IUBMB entry for 1.2.1.58

• KEGG entry for 1.2.1.58

• BRENDA entry for 1.2.1.58

• NiceZyme view of 1.2.1.58

• EC2PDB: PDB structures for 1.2.1.58

• PRIAM entry for 1.2.1.58

• PUMA2 entry for 1.2.1.58

• IntEnz: Integrated Enzyme entry for 1.2.1.58

• MetaCyc entry for 1.2.1.58

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047110: phenylglyoxylate dehydrogenase (acylating)

• AMIGO entry for GO code 0047110: phenylglyoxylate dehydrogenase (acylating)