Phenylalanine decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a phenylalanine decarboxylase (EC 4.1.1.53) is an enzyme that catalyzes the chemical reaction

L-phenylalanine phenylethylamine + CO₂

Hence, this enzyme has one substrate, L-phenylalanine, and two products, phenylethylamine and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-phenylalanine carboxy-lyase (phenylethylamine-forming). Other names in common use include L-phenylalanine decarboxylase, aromatic L-amino acid decarboxylase, and L-phenylalanine carboxy-lyase. This enzyme participates in phenylalanine metabolism. It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 4.1.1.53
• BRENDA references for 4.1.1.53 (Recommended.)
• PubMed references for 4.1.1.53
• PubMed Central references for 4.1.1.53
• Google Scholar references for 4.1.1.53
• LOVENBERG W, WEISSBACH H, UDENFRIEND S (1962). "Aromatic L-amino acid decarboxylase". J. Biol. Chem. 237: 89–93. PMID 14466899. 
• Schulz AR, Oliner L (1967). "The possible role of thyroid aromatic amino acid decarboxylase in thyroxine biosynthesis". Life. Sci. 6: 873–80. doi:10.1016/0024-3205(67)90291-3. PMID 6034195. 

[edit] External links

The CAS registry number for this enzyme class is 9075-72-3.

• IUBMB entry for 4.1.1.53

• KEGG entry for 4.1.1.53

• BRENDA entry for 4.1.1.53

• NiceZyme view of 4.1.1.53

• EC2PDB: PDB structures for 4.1.1.53

• PRIAM entry for 4.1.1.53

• PUMA2 entry for 4.1.1.53

• IntEnz: Integrated Enzyme entry for 4.1.1.53

• MetaCyc entry for 4.1.1.53

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050174: phenylalanine decarboxylase

• AMIGO entry for GO code 0050174: phenylalanine decarboxylase