Phenylalanine-tRNA ligase
From Wikipedia, the free encyclopedia
In enzymology, a phenylalanine-tRNA ligase (EC 6.1.1.20) is an enzyme that catalyzes the chemical reaction
- ATP + L-phenylalanine + tRNAPhe
AMP + diphosphate + L-phenylalanyl-tRNAPhe
The 3 substrates of this enzyme are ATP, L-phenylalanine, and tRNA(Phe), whereas its 3 products are AMP, diphosphate, and L-phenylalanyl-tRNA(Phe).
This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-phenylalanine:tRNAPhe ligase (AMP-forming). Other names in common use include phenylalanyl-tRNA synthetase, phenylalanyl-transfer ribonucleate synthetase, phenylalanine-tRNA synthetase, phenylalanyl-transfer RNA synthetase, phenylalanyl-tRNA ligase, phenylalanyl-transfer RNA ligase, L-phenylalanyl-tRNA synthetase, and phenylalanine translase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and aminoacyl-trna biosynthesis.
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[edit] Structural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1B70, 1B7Y, 1EIY, 1JJC, 1PYS, 2AKW, 2ALY, 2AMC, 2CXI, and 2IY5.
[edit] References
- IUBMB entry for 6.1.1.20
- BRENDA references for 6.1.1.20 (Recommended.)
- PubMed references for 6.1.1.20
- PubMed Central references for 6.1.1.20
- Google Scholar references for 6.1.1.20
- Stulberg MP (1967). "The isolation and properties of phenylalanyl ribonucleic acid synthetase from Escherichia coli B". J. Biol. Chem. 242: 1060–4. PMID 5335910.
[edit] External links
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- The CAS registry number for this enzyme class is 9055-66-7.
[edit] Gene Ontology (GO) codes
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