Phenylacetate-CoA ligase

From Wikipedia, the free encyclopedia

In enzymology, a phenylacetate-CoA ligase (EC 6.2.1.30) is an enzyme that catalyzes the chemical reaction

ATP + phenylacetate + CoA AMP + diphosphate + phenylacetyl-CoA

The 3 substrates of this enzyme are ATP, phenylacetate, and CoA, whereas its 3 products are AMP, diphosphate, and phenylacetyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is phenylacetate:CoA ligase (AMP-forming). Other names in common use include phenacyl coenzyme A synthetase, phenylacetyl-CoA ligase, PA-CoA ligase, and phenylacetyl-CoA ligase (AMP-forming). This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

[edit] References

• IUBMB entry for 6.2.1.30
• BRENDA references for 6.2.1.30 (Recommended.)
• PubMed references for 6.2.1.30
• PubMed Central references for 6.2.1.30
• Google Scholar references for 6.2.1.30
• Martinez-Blanco H, Reglero A, Rodriguez-Aparicio LB, Luengo JM (1990). "Purification and biochemical characterization of phenylacetyl-CoA ligase from Pseudomonas putida. A specific enzyme for the catabolism of phenylacetic acid". J. Biol. Chem. 265: 7084–90. PMID 2324116. 

[edit] External links

The CAS registry number for this enzyme class is 57219-71-3.

• IUBMB entry for 6.2.1.30

• KEGG entry for 6.2.1.30

• BRENDA entry for 6.2.1.30

• NiceZyme view of 6.2.1.30

• EC2PDB: PDB structures for 6.2.1.30

• PRIAM entry for 6.2.1.30

• PUMA2 entry for 6.2.1.30

• IntEnz: Integrated Enzyme entry for 6.2.1.30

• MetaCyc entry for 6.2.1.30

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047475: phenylacetate-CoA ligase

• AMIGO entry for GO code 0047475: phenylacetate-CoA ligase