PHC3

From Wikipedia, the free encyclopedia

Polyhomeotic homolog 3 (Drosophila)

Identifiers

PHC3; DKFZp313K1221; EDR3; FLJ12729; FLJ12967; HPH3; MGC88144

External IDs

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024947 (mRNA)
NP_079223 (protein)

NM_153421 (mRNA)
NP_700470 (protein)

Location

Chr 3: 171.3 - 171.38 Mb

Chr 3: 31.1 - 31.16 Mb

Pubmed search

[1]

[2]

Polyhomeotic homolog 3 (Drosophila), also known as PHC3, is a human gene.^[1]

[edit] References

^ Entrez Gene: PHC3 polyhomeotic homolog 3 (Drosophila).

[edit] Further reading

Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.". Mol. Cell. Biol. 22 (17): 6070–8. PMID 12167701.
Tonkin E, Hagan DM, Li W, Strachan T (2002). "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family.". Hum. Genet. 111 (4-5): 435–42. doi:10.1007/s00439-002-0814-3. PMID 12384788.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Deshpande AM, Akunowicz JD, Reveles XT, et al. (2007). "PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors.". Oncogene 26 (12): 1714–22. doi:10.1038/sj.onc.1209988. PMID 17001316.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.