PHC1

From Wikipedia, the free encyclopedia

Polyhomeotic homolog 1 (Drosophila)

Identifiers

PHC1; EDR1; HPH1; RAE28

External IDs

Gene ontology
Molecular Function:	• DNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_004426 (mRNA)
NP_004417 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 12: 54.09 - 54.09 Mb

n/a

Pubmed search

[1]

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Polyhomeotic homolog 1 (Drosophila), also known as PHC1, is a human gene.^[1]

This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: PHC1 polyhomeotic homolog 1 (Drosophila).

[edit] Further reading

Alkema MJ, Bronk M, Verhoeven E, et al. (1997). "Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.". Genes Dev. 11 (2): 226–40. PMID 9009205.
Gunster MJ, Satijn DP, Hamer KM, et al. (1997). "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.". Mol. Cell. Biol. 17 (4): 2326–35. PMID 9121482.
Satijn DP, Gunster MJ, van der Vlag J, et al. (1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.". Mol. Cell. Biol. 17 (7): 4105–13. PMID 9199346.
Tomotsune D, Takihara Y, Berger J, et al. (2000). "A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro.". Differentiation 65 (4): 229–39. PMID 10653359.
Ohta H, Tokimasa S, Zou Z, et al. (2000). "Structure and chromosomal localization of the RAE28/HPH1 gene, a human homologue of the polyhomeotic gene.". DNA Seq. 11 (1-2): 61–73. PMID 10902910.
Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.". Mol. Cell. Biol. 22 (17): 6070–8. PMID 12167701.
Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.". Development 129 (18): 4171–83. PMID 12183370.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Luo L, Yang X, Takihara Y, et al. (2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions.". Nature 427 (6976): 749–53. doi:10.1038/nature02305. PMID 14973489.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Wang H, Wang L, Erdjument-Bromage H, et al. (2004). "Role of histone H2A ubiquitination in Polycomb silencing.". Nature 431 (7010): 873–8. doi:10.1038/nature02985. PMID 15386022.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Voncken JW, Niessen H, Neufeld B, et al. (2005). "MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.". J. Biol. Chem. 280 (7): 5178–87. doi:10.1074/jbc.M407155200. PMID 15563468.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.