PHB2

From Wikipedia, the free encyclopedia

Prohibitin 2

Identifiers

PHB2; p22; BAP; BCAP37; Bap37; MGC117268; PNAS-141; REA

External IDs

OMIM: 610704 MGI: 102520 HomoloGene: 5263

Gene ontology
Molecular Function:	• receptor activity • protein binding • specific transcriptional repressor activity • estrogen receptor binding
Cellular Component:	• nucleus • mitochondrion • mitochondrial inner membrane • membrane
Biological Process:	• transcription • regulation of transcription, DNA-dependent • negative regulation of transcription

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_007273 (mRNA)
NP_009204 (protein)

NM_007531 (mRNA)
NP_031557 (protein)

Location

n/a

Chr 6: 124.68 - 124.68 Mb

Pubmed search

[1]

[2]

Prohibitin 2, also known as PHB2, is a human gene.^[1]

[edit] References

^ Entrez Gene: PHB2 prohibitin 2.

[edit] Further reading

Martini PG, Katzenellenbogen BS (2003). "Modulation of estrogen receptor activity by selective coregulators.". J. Steroid Biochem. Mol. Biol. 85 (2-5): 117-22. PMID 12943695.
Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.". Genome Res. 6 (4): 314-26. PMID 8723724.
Ansari-Lari MA, Shen Y, Muzny DM, et al. (1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.". Genome Res. 7 (3): 268-80. PMID 9074930.
Coates PJ, Jamieson DJ, Smart K, et al. (1997). "The prohibitin family of mitochondrial proteins regulate replicative lifespan.". Curr. Biol. 7 (8): 607-10. PMID 9259555.
Montano MM, Ekena K, Delage-Mourroux R, et al. (1999). "An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6947-52. PMID 10359819.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543-8. doi:10.1073/pnas.160270997. PMID 10931946.
Martini PG, Delage-Mourroux R, Kraichely DM, Katzenellenbogen BS (2000). "Prothymosin alpha selectively enhances estrogen receptor transcriptional activity by interacting with a repressor of estrogen receptor activity.". Mol. Cell. Biol. 20 (17): 6224-32. PMID 10938099.
Coates PJ, Nenutil R, McGregor A, et al. (2001). "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence.". Exp. Cell Res. 265 (2): 262-73. doi:10.1006/excr.2001.5166. PMID 11302691.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Kurtev V, Margueron R, Kroboth K, et al. (2004). "Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.". J. Biol. Chem. 279 (23): 24834-43. doi:10.1074/jbc.M312300200. PMID 15140878.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12.". Nature 440 (7082): 346-51. doi:10.1038/nature04569. PMID 16541075.
Kasashima K, Ohta E, Kagawa Y, Endo H (2007). "Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2.". J. Biol. Chem. 281 (47): 36401-10. doi:10.1074/jbc.M605260200. PMID 17008324.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Takata H, Matsunaga S, Morimoto A, et al. (2007). "PHB2 protects sister-chromatid cohesion in mitosis.". Curr. Biol. 17 (15): 1356-61. doi:10.1016/j.cub.2007.07.009. PMID 17656096.