PGRMC1

From Wikipedia, the free encyclopedia

Progesterone receptor membrane component 1

Identifiers

PGRMC1; HPR6.6; MPR

External IDs

OMIM: 300435 MGI: 1858305 HomoloGene: 48457

Gene ontology
Molecular Function:	• receptor activity • steroid binding • lipid binding • heme binding • transition metal ion binding
Cellular Component:	• endoplasmic reticulum • microsome • integral to plasma membrane • cell surface • membrane

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006667 (mRNA)
NP_006658 (protein)

NM_016783 (mRNA)
NP_058063 (protein)

Location

Chr X: 118.25 - 118.26 Mb

Chr X: 33.03 - 33.04 Mb

Pubmed search

[1]

[2]

Progesterone receptor membrane component 1, also known as PGRMC1, is a human gene.^[1]

Progesterone binding protein is a putative steroid membrane receptor. The protein is expressed predominantly in the liver and kidney.^[1]

[edit] References

^ ^a ^b Entrez Gene: PGRMC1 progesterone receptor membrane component 1.

[edit] Further reading

Gerdes D, Wehling M, Leube B, Falkenstein E (1998). "Cloning and tissue expression of two putative steroid membrane receptors.". Biol. Chem. 379 (7): 907-11. PMID 9705155.
Bernauer S, Wehling M, Gerdes D, Falkenstein E (2002). "The human membrane progesterone receptor gene: genomic structure and promoter analysis.". DNA Seq. 12 (1): 13-25. PMID 11697142.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.". J. Biol. Chem. 278 (9): 7607-16. doi:10.1074/jbc.M210455200. PMID 12493773.
Hand RA, Craven RJ (2004). "Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 human breast cancer cells.". J. Cell. Biochem. 90 (3): 534-47. doi:10.1002/jcb.10648. PMID 14523988.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lösel R, Breiter S, Seyfert M, et al. (2005). "Classic and non-classic progesterone receptors are both expressed in human spermatozoa.". Horm. Metab. Res. 37 (1): 10-4. doi:10.1055/s-2005-861023. PMID 15702432.
Suchanek M, Radzikowska A, Thiele C (2005). "Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells.". Nat. Methods 2 (4): 261-7. doi:10.1038/nmeth752. PMID 15782218.
Crudden G, Loesel R, Craven RJ (2005). "Overexpression of the cytochrome p450 activator hpr6 (heme-1 domain protein/human progesterone receptor) in tumors.". Tumour Biol. 26 (3): 142-6. doi:10.1159/000086485. PMID 15970648.
Crudden G, Chitti RE, Craven RJ (2006). "Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs.". J. Pharmacol. Exp. Ther. 316 (1): 448-55. doi:10.1124/jpet.105.094631. PMID 16234411.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391-6. doi:10.1073/pnas.0507066103. PMID 16565220.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Hughes AL, Powell DW, Bard M, et al. (2007). "Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.". Cell Metab. 5 (2): 143-9. doi:10.1016/j.cmet.2006.12.009. PMID 17276356.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.