PGK1

From Wikipedia, the free encyclopedia

Phosphoglycerate kinase 1

PDB rendering based on 1hdi.

Available structures: 1hdi, 1kf0, 1vjc, 1vjd

Identifiers

Symbol(s)

PGK1; MGC117307; MGC142128; MGC8947; MIG10; PGKA

External IDs

OMIM: 311800 MGI: 97555 HomoloGene: 21542

Gene ontology
Molecular Function:	• nucleotide binding • phosphoglycerate kinase activity • ATP binding • transferase activity
Biological Process:	• glycolysis • phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_000291 (mRNA)
NP_000282 (protein)

NM_008828 (mRNA)
NP_032854 (protein)

Location

Chr X: 77.25 - 77.27 Mb

n/a

Pubmed search

[1]

[2]

Phosphoglycerate kinase 1, also known as PGK1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PGK1 phosphoglycerate kinase 1.

[edit] Further reading

Vishwanatha JK, Jindal HK, Davis RG (1992). "The role of primer recognition proteins in DNA replication: association with nuclear matrix in HeLa cells.". J. Cell. Sci. 101 ( Pt 1): 25–34. PMID 1533225.
Fujii H, Kanno H, Hirono A, et al. (1992). "A single amino acid substitution (157 Gly----Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria.". Blood 79 (6): 1582–5. PMID 1547346.
Maeda M, Bawle EV, Kulkarni R, et al. (1992). "Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation.". Blood 79 (10): 2759–62. PMID 1586722.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.
Kumble KD, Vishwanatha JK (1992). "Immunoelectron microscopic analysis of the intracellular distribution of primer recognition proteins, annexin 2 and phosphoglycerate kinase, in normal and transformed cells.". J. Cell. Sci. 99 ( Pt 4): 751–8. PMID 1837552.
Maeda M, Yoshida A (1991). "Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu----Pro substitution caused by T/A----C/G transition in exon 3.". Blood 77 (6): 1348–52. PMID 2001457.
Jindal HK, Vishwanatha JK (1990). "Functional identity of a primer recognition protein as phosphoglycerate kinase.". J. Biol. Chem. 265 (12): 6540–3. PMID 2324090.
Johnson P, Friedmann T (1990). "Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK.". Gene 88 (2): 207–13. PMID 2347494.
Pfeifer GP, Steigerwald SD, Mueller PR, et al. (1989). "Genomic sequencing and methylation analysis by ligation mediated PCR.". Science 246 (4931): 810–3. PMID 2814502.
Michelson AM, Blake CC, Evans ST, Orkin SH (1985). "Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain.". Proc. Natl. Acad. Sci. U.S.A. 82 (20): 6965–9. PMID 2995995.
McCarrey JR, Thomas K (1987). "Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene.". Nature 326 (6112): 501–5. doi:10.1038/326501a0. PMID 3453121.
Singer-Sam J, Keith DH, Tani K, et al. (1985). "Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]". Gene 32 (3): 409–17. PMID 6099325.
Michelson AM, Markham AF, Orkin SH (1983). "Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.". Proc. Natl. Acad. Sci. U.S.A. 80 (2): 472–6. PMID 6188151.
Fujii H, Yoshida A (1981). "Molecular abnormality of phosphoglycerate kinase-Uppsala associated with chronic nonspherocytic hemolytic anemia.". Proc. Natl. Acad. Sci. U.S.A. 77 (9): 5461–5. PMID 6933565.
Fujii H, Chen SH, Akatsuka J, et al. (1981). "Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia.". Proc. Natl. Acad. Sci. U.S.A. 78 (4): 2587–90. PMID 6941312.
Huang IY, Welch CD, Yoshida A (1980). "Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence.". J. Biol. Chem. 255 (13): 6412–20. PMID 7391027.
Fujii H, Krietsch WK, Yoshida A (1980). "A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK München) associated with enzyme deficiency.". J. Biol. Chem. 255 (13): 6421–3. PMID 7391028.
Huang IY, Fujii H, Yoshida A (1981). "Structure and function of normal and variant human phosphoglycerate kinase.". Hemoglobin 4 (5-6): 601–9. PMID 7440217.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. PMID 7821789.
Hershkovitz M, Riggs AD (1995). "Metaphase chromosome analysis by ligation-mediated PCR: heritable chromatin structure and a comparison of active and inactive X chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2379–83. PMID 7892275.