PGDS

From Wikipedia, the free encyclopedia

Prostaglandin D2 synthase, hematopoietic

PDB rendering based on 1iyh.

Available structures: 1iyh, 1iyi, 1v40, 2cvd

Identifiers

Symbol(s)

PGDS;

External IDs

OMIM: 602598 MGI: 1859384 HomoloGene: 40949

Gene ontology
Molecular Function:	• prostaglandin-D synthase activity • isomerase activity
Cellular Component:	• cytoplasm
Biological Process:	• prostaglandin biosynthetic process • fatty acid biosynthetic process • signal transduction • cell-cell signaling • locomotory behavior

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014485 (mRNA)
NP_055300 (protein)

NM_019455 (mRNA)
NP_062328 (protein)

Location

Chr 4: 95.44 - 95.48 Mb

Chr 6: 65.05 - 65.07 Mb

Pubmed search

[1]

[2]

Prostaglandin D2 synthase, hematopoietic, also known as PGDS, is a human gene.^[1]

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.^[1]

[edit] References

^ ^a ^b Entrez Gene: PGDS prostaglandin D2 synthase, hematopoietic.

[edit] Further reading

Kanaoka Y, Urade Y (2004). "Hematopoietic prostaglandin D synthase.". Prostaglandins Leukot. Essent. Fatty Acids 69 (2-3): 163–7. PMID 12895599.
Kanaoka Y, Ago H, Inagaki E, et al. (1997). "Cloning and crystal structure of hematopoietic prostaglandin D synthase.". Cell 90 (6): 1085–95. PMID 9323136.
Mahmud I, Ueda N, Yamaguchi H, et al. (1997). "Prostaglandin D synthase in human megakaryoblastic cells.". J. Biol. Chem. 272 (45): 28263–6. PMID 9353279.
Suzuki T, Watanabe K, Kanaoka Y, et al. (1998). "Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester.". Biochem. Biophys. Res. Commun. 241 (2): 288–93. doi:10.1006/bbrc.1997.7803. PMID 9425264.
Tokugawa Y, Kunishige I, Kubota Y, et al. (1998). "Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma.". Biol. Reprod. 58 (2): 600–7. PMID 9475419.
Pinzar E, Kanaoka Y, Inui T, et al. (2000). "Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4903–7. doi:10.1073/pnas.090093997. PMID 10781097.
Kanaoka Y, Fujimori K, Kikuno R, et al. (2000). "Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase.". Eur. J. Biochem. 267 (11): 3315–22. PMID 10824118.
Fujimori K, Kanaoka Y, Sakaguchi Y, Urade Y (2001). "Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1.". J. Biol. Chem. 275 (51): 40511–6. doi:10.1074/jbc.M007688200. PMID 10998423.
Sui D, Wilson JE (2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase.". Arch. Biochem. Biophys. 382 (2): 262–74. doi:10.1006/abbi.2000.2019. PMID 11068878.
Jowsey IR, Thomson AM, Flanagan JU, et al. (2001). "Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases.". Biochem. J. 359 (Pt 3): 507–16. PMID 11672424.
Noguchi E, Shibasaki M, Kamioka M, et al. (2002). "New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes.". Clin. Exp. Allergy 32 (1): 93–6. PMID 12002745.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Inoue T, Irikura D, Okazaki N, et al. (2003). "Mechanism of metal activation of human hematopoietic prostaglandin D synthase.". Nat. Struct. Biol. 10 (4): 291–6. doi:10.1038/nsb907. PMID 12627223.
Ando M, Murakami Y, Kojima F, et al. (2003). "Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin.". Am. J. Respir. Cell Mol. Biol. 28 (5): 582–91. doi:10.1165/rcmb.2002-0162OC. PMID 12707014.
Inoue T, Okano Y, Kado Y, et al. (2005). "First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase.". J. Biochem. 135 (3): 279–83. PMID 15113825.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.