PGC (gene)

From Wikipedia, the free encyclopedia

Progastricsin (pepsinogen C)

PDB rendering based on 1avf.

Available structures: 1avf, 1htr

Identifiers

Symbol(s)

PGC;

External IDs

OMIM: 169740 MGI: 98909 HomoloGene: 55669

Gene ontology
Molecular Function:	• pepsin A activity • peptidase activity
Cellular Component:	• extracellular space
Biological Process:	• proteolysis • digestion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002630 (mRNA)
NP_002621 (protein)

NM_025973 (mRNA)
NP_080249 (protein)

Location

Chr 6: 41.81 - 41.82 Mb

Chr 17: 47.19 - 47.2 Mb

Pubmed search

[1]

[2]

Progastricsin (pepsinogen C), also known as PGC, is a human gene.^[1]

[edit] References

^ Entrez Gene: PGC progastricsin (pepsinogen C).

[edit] Further reading

Richter C, Tanaka T, Yada RY (1998). "Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin.". Biochem. J. 335 ( Pt 3): 481–90. PMID 9794784.
Sánchez LM, Freije JP, Merino AM, et al. (1992). "Isolation and characterization of a pepsin C zymogen produced by human breast tissues.". J. Biol. Chem. 267 (34): 24725–31. PMID 1280267.
Ichinose M, Miki K, Wong RN, et al. (1991). "Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer.". Jpn. J. Cancer Res. 82 (6): 686–92. PMID 1906854.
Athauda SB, Tanji M, Kageyama T, Takahashi K (1990). "A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.". J. Biochem. 106 (5): 920–7. PMID 2515193.
Pals G, Azuma T, Mohandas TK, et al. (1989). "Human pepsinogen C (progastricsin) polymorphism: evidence for a single locus located at 6p21.1-pter.". Genomics 4 (2): 137–48. PMID 2567697.
Taggart RT, Cass LG, Mohandas TK, et al. (1989). "Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A.". J. Biol. Chem. 264 (1): 375–9. PMID 2909526.
Westerveld BD, Pals G, Bosma A, et al. (1987). "Gastric proteases in Barrett's esophagus.". Gastroenterology 93 (4): 774–8. PMID 3305135.
Hayano T, Sogawa K, Ichihara Y, et al. (1988). "Primary structure of human pepsinogen C gene.". J. Biol. Chem. 263 (3): 1382–5. PMID 3335549.
Foltmann B, Jensen AL (1983). "Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart.". Eur. J. Biochem. 128 (1): 63–70. PMID 6816595.
Moore SA, Sielecki AR, Chernaia MM, et al. (1995). "Crystal and molecular structures of human progastricsin at 1.62 A resolution.". J. Mol. Biol. 247 (3): 466–85. doi:10.1006/jmbi.1994.0154. PMID 7714902.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Aabakken L, Axelsson CK, Szecsi PB (1993). "Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.". Scand. J. Gastroenterol. 28 (6): 557–60. PMID 8322031.
Aoki T, Tomaki E, Morikawa J, et al. (1997). "Purification of pepsinogens from human urine and electrophoretic analysis by caseogram print.". Biochem. Mol. Biol. Int. 39 (6): 1147–56. PMID 8876968.
Diamandis EP, Nadkarni S, Bhaumik B, et al. (1997). "Immunofluorometric assay of pepsinogen C and preliminary clinical applications.". Clin. Chem. 43 (8 Pt 1): 1365–71. PMID 9267315.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Khan AR, Cherney MM, Tarasova NI, James MN (1998). "Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin.". Nat. Struct. Biol. 4 (12): 1010–5. PMID 9406551.
Plebani M, Basso D, Navaglia F, DiMario F (1998). "Helicobacter pylori genotypes influence serum pepsinogen C levels.". Helicobacter 2 (4): 172–5. PMID 9421118.
Rojo JV, Merino AM, González LO, Vizoso F (2003). "Expression and clinical significance of pepsinogen C in epithelial ovarian carcinomas.". Eur. J. Obstet. Gynecol. Reprod. Biol. 104 (1): 58–63. PMID 12128264.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.