PFN2

From Wikipedia, the free encyclopedia

Profilin 2

PDB rendering based on 1d1j.

Available structures: 1d1j

Identifiers

Symbol(s)

PFN2; D3S1319E; PFL

External IDs

OMIM: 176590 MGI: 97550 HomoloGene: 1974

Gene ontology
Molecular Function:	• actin binding • protein binding • phosphatidylinositol-4,5-bisphosphate binding
Cellular Component:	• actin cytoskeleton
Biological Process:	• cytoskeleton organization and biogenesis • regulation of actin polymerization and/or depolymerization • actin cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002628 (mRNA)
NP_002619 (protein)

NM_019410 (mRNA)
NP_062283 (protein)

Location

Chr 3: 151.17 - 151.17 Mb

Chr 3: 57.93 - 57.94 Mb

Pubmed search

[1]

[2]

Profilin 2, also known as PFN2, is a human gene.^[1]

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PFN2 profilin 2.

[edit] Further reading

Qualmann B, Kessels MM (2003). "Endocytosis and the cytoskeleton.". Int. Rev. Cytol. 220: 93–144. PMID 12224553.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.
Kwiatkowski DJ, Bruns GA (1988). "Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis.". J. Biol. Chem. 263 (12): 5910–5. PMID 3356709.
Reinhard M, Giehl K, Abel K, et al. (1995). "The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.". EMBO J. 14 (8): 1583–9. PMID 7737110.
Gieselmann R, Kwiatkowski DJ, Janmey PA, Witke W (1995). "Distinct biochemical characteristics of the two human profilin isoforms.". Eur. J. Biochem. 229 (3): 621–8. PMID 7758455.
Honoré B, Madsen P, Andersen AH, Leffers H (1993). "Cloning and expression of a novel human profilin variant, profilin II.". FEBS Lett. 330 (2): 151–5. PMID 8365484.
Naylor SL, Carritt B, Boileau C, et al. (1996). "Report of the sixth international workshop on human chromosome 3 mapping 1995.". Cytogenet. Cell Genet. 72 (4): 255–70. PMID 8641130.
Joensuu T, Blanco G, Pakarinen L, et al. (1997). "Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region.". Genomics 38 (3): 255–63. PMID 8975700.
Witke W, Podtelejnikov AV, Di Nardo A, et al. (1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.". EMBO J. 17 (4): 967–76. doi:10.1093/emboj/17.4.967. PMID 9463375.
Nodelman IM, Bowman GD, Lindberg U, Schutt CE (2000). "X-ray structure determination of human profilin II: A comparative structural analysis of human profilins.". J. Mol. Biol. 294 (5): 1271–85. doi:10.1006/jmbi.1999.3318. PMID 10600384.
Harbeck B, Hüttelmaier S, Schluter K, et al. (2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin.". J. Biol. Chem. 275 (40): 30817–25. doi:10.1074/jbc.M005066200. PMID 10882740.
Lambrechts A, Kwiatkowski AV, Lanier LM, et al. (2000). "cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains.". J. Biol. Chem. 275 (46): 36143–51. doi:10.1074/jbc.M006274200. PMID 10945997.
Lambrechts A, Braun A, Jonckheere V, et al. (2000). "Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties.". Mol. Cell. Biol. 20 (21): 8209–19. PMID 11027290.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tojo H, Kaieda I, Hattori H, et al. (2004). "The Formin family protein, formin homolog overexpressed in spleen, interacts with the insulin-responsive aminopeptidase and profilin IIa.". Mol. Endocrinol. 17 (7): 1216–29. doi:10.1210/me.2003-0056. PMID 12677009.
Da Silva JS, Medina M, Zuliani C, et al. (2003). "RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability.". J. Cell Biol. 162 (7): 1267–79. doi:10.1083/jcb.200304021. PMID 14517206.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lederer M, Jockusch BM, Rothkegel M (2005). "Profilin regulates the activity of p42POP, a novel Myb-related transcription factor.". J. Cell. Sci. 118 (Pt 2): 331–41. doi:10.1242/jcs.01618. PMID 15615774.