PFKFB3

From Wikipedia, the free encyclopedia

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

PDB rendering based on 2axn.

Available structures: 2axn

Identifiers

Symbol(s)

PFKFB3; IPFK2; PFK2

External IDs

OMIM: 605319 MGI: 2181202 HomoloGene: 88708

Gene ontology
Molecular Function:	• nucleotide binding • catalytic activity • 6-phosphofructo-2-kinase activity • fructose-2,6-bisphosphate 2-phosphatase activity • ATP binding • kinase activity • transferase activity • hydrolase activity • identical protein binding
Cellular Component:	• cellular_component
Biological Process:	• fructose 2,6-bisphosphate metabolic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004566 (mRNA)
NP_004557 (protein)

NM_133232 (mRNA)
NP_573495 (protein)

Location

Chr 10: 6.23 - 6.32 Mb

Chr 2: 11.39 - 11.42 Mb

Pubmed search

[1]

[2]

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, also known as PFKFB3, is a human gene.^[1]

[edit] References

^ Entrez Gene: PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3.

[edit] Further reading

Sakai A, Kato M, Fukasawa M, et al. (1996). "Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta.". J. Biochem. 119 (3): 506–11. PMID 8830046.
Hamilton JA, Callaghan MJ, Sutherland RL, Watts CK (1997). "Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.". Mol. Endocrinol. 11 (4): 490–502. PMID 9092801.
Nicholl J, Hamilton JA, Sutherland GR, et al. (1997). "The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) map position 10p14-p15.". Chromosome Res. 5 (2): 150. PMID 9146922.
Sakakibara R, Kato M, Okamura N, et al. (1997). "Characterization of a human placental fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase.". J. Biochem. 122 (1): 122–8. PMID 9276680.
Manzano A, Rosa JL, Ventura F, et al. (1999). "Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3).". Cytogenet. Cell Genet. 83 (3-4): 214–7. PMID 10072580.
Chesney J, Mitchell R, Benigni F, et al. (1999). "An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 3047–52. PMID 10077634.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. PMID 10508479.
Fukasawa M, Takayama E, Shinomiya N, et al. (2000). "Identification of the promoter region of human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.". Biochem. Biophys. Res. Commun. 267 (3): 703–8. doi:10.1006/bbrc.1999.2022. PMID 10673355.
Kessler R, Eschrich K (2001). "Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain.". Brain Res. Mol. Brain Res. 87 (2): 190–5. PMID 11245921.
Navarro-Sabaté A, Manzano A, Riera L, et al. (2001). "The human ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3): promoter characterization and genomic structure.". Gene 264 (1): 131–8. PMID 11245987.
Atsumi T, Chesney J, Metz C, et al. (2002). "High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers.". Cancer Res. 62 (20): 5881–7. PMID 12384552.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Riera L, Obach M, Navarro-Sabaté A, et al. (2003). "Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation.". FEBS Lett. 550 (1-3): 23–9. PMID 12935880.
Mahlknecht U, Chesney J, Hoelzer D, Bucala R (2004). "Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2).". Int. J. Oncol. 23 (4): 883–91. PMID 12963966.
Obach M, Navarro-Sabaté A, Caro J, et al. (2005). "6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia.". J. Biol. Chem. 279 (51): 53562–70. doi:10.1074/jbc.M406096200. PMID 15466858.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Manes NP, El-Maghrabi MR (2005). "The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate.". Arch. Biochem. Biophys. 438 (2): 125–36. doi:10.1016/j.abb.2005.04.011. PMID 15896703.
Bando H, Atsumi T, Nishio T, et al. (2005). "Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer.". Clin. Cancer Res. 11 (16): 5784–92. doi:10.1158/1078-0432.CCR-05-0149. PMID 16115917.
Atsumi T, Nishio T, Niwa H, et al. (2006). "Expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation.". Diabetes 54 (12): 3349–57. PMID 16306349.
Minchenko OH, Ogura T, Opentanova IL, et al. (2006). "Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation.". Mol. Cell. Biochem. 280 (1-2): 227–34. doi:10.1007/s11010-005-8009-6. PMID 16311927.