PFDN4

From Wikipedia, the free encyclopedia

Prefoldin subunit 4

Identifiers

PFDN4; C1; PFD4

External IDs

OMIM: 604898 MGI: 1923512 HomoloGene: 37645

Gene ontology
Molecular Function:	• unfolded protein binding • chaperone binding
Cellular Component:	• cytosol
Biological Process:	• protein folding • chaperonin-mediated tubulin folding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_002623 (mRNA)
NP_002614 (protein)

XM_001005759 (mRNA)
XP_001005759 (protein)

Location

Chr 20: 52.26 - 52.27 Mb

Chr 2: 170.19 - 170.21 Mb

Pubmed search

[1]

[2]

Prefoldin subunit 4, also known as PFDN4, is a human gene.^[1]

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.^[1]

[edit] References

^ ^a ^b Entrez Gene: PFDN4 prefoldin subunit 4.

[edit] Further reading

Hartl FU, Hayer-Hartl M (2002). "Molecular chaperones in the cytosol: from nascent chain to folded protein.". Science 295 (5561): 1852–8. doi:10.1126/science.1068408. PMID 11884745.
Iijima M, Kano Y, Nohno T, Namba M (1996). "Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines.". Acta Med. Okayama 50 (2): 73–7. PMID 8744932.
Vainberg IE, Lewis SA, Rommelaere H, et al. (1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.". Cell 93 (5): 863–73. PMID 9630229.
Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins.". J. Cell Biol. 145 (2): 265–77. PMID 10209023.
Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface.". Nat. Struct. Biol. 6 (11): 990–1. doi:10.1038/14870. PMID 10542082.
Collins C, Volik S, Kowbel D, et al. (2001). "Comprehensive genome sequence analysis of a breast cancer amplicon.". Genome Res. 11 (6): 1034–42. doi:10.1101/gr.174301. PMID 11381030.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Martín-Benito J, Boskovic J, Gómez-Puertas P, et al. (2003). "Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT.". EMBO J. 21 (23): 6377–86. PMID 12456645.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.". Science 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539.
Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding.". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200. PMID 14634002.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.