PFDN2

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Prefoldin subunit 2
Identifiers
Symbol(s) PFDN2; PFD2
External IDs MGI: 1276111 HomoloGene: 7887
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5202 18637
Ensembl ENSG00000143256 ENSMUSG00000006412
Uniprot Q9UHV9 O70591
Refseq NM_012394 (mRNA)
NP_036526 (protein)		 NM_011070 (mRNA)
NP_035200 (protein)
Location Chr 1: 159.34 - 159.35 Mb Chr 1: 173.18 - 173.19 Mb
Pubmed search [1] [2]

Prefoldin subunit 2, also known as PFDN2, is a human gene.[1]

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.[1]

[edit] References

  1. ^ a b Entrez Gene: PFDN2 prefoldin subunit 2.

[edit] Further reading

  • Vainberg IE, Lewis SA, Rommelaere H, et al. (1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.". Cell 93 (5): 863–73. PMID 9630229. 
  • Eddleston J, Murdoch JN, Copp AJ, Stanier P (1999). "Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).". Genomics 56 (2): 149–59. doi:10.1006/geno.1998.5701. PMID 10051400. 
  • Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins.". J. Cell Biol. 145 (2): 265–77. PMID 10209023. 
  • Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface.". Nat. Struct. Biol. 6 (11): 990–1. doi:10.1038/14870. PMID 10542082. 
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946. 
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.". Science 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539. 
  • Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding.". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200. PMID 14634002. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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