PFDN1

From Wikipedia, the free encyclopedia


Prefoldin subunit 1
Identifiers
Symbol(s) PFDN1; PDF; PFD1
External IDs OMIM: 604897 MGI: 1914449 HomoloGene: 37644
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5201 67199
Ensembl ENSG00000113068 ENSMUSG00000024346
Uniprot O60925 Q8CEH4
Refseq NM_002622 (mRNA)
NP_002613 (protein)		 NM_026027 (mRNA)
NP_080303 (protein)
Location Chr 5: 139.6 - 139.66 Mb Chr 18: 36.53 - 36.58 Mb
Pubmed search [1] [2]

Prefoldin subunit 1, also known as PFDN1, is a human gene.[1]

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.[1]

[edit] References

  1. ^ a b Entrez Gene: PFDN1 prefoldin subunit 1.

[edit] Further reading

  • Hartl FU, Hayer-Hartl M (2002). "Molecular chaperones in the cytosol: from nascent chain to folded protein.". Science 295 (5561): 1852–8. doi:10.1126/science.1068408. PMID 11884745. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Iijima M, Kano Y, Nohno T, Namba M (1996). "Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines.". Acta Med. Okayama 50 (2): 73–7. PMID 8744932. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Vainberg IE, Lewis SA, Rommelaere H, et al. (1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.". Cell 93 (5): 863–73. PMID 9630229. 
  • Horrigan SK, Bartoloni L, Speer MC, et al. (1999). "A radiation hybrid breakpoint map of the acute myeloid leukemia (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of chromosome 5q31 localizing 122 expressed sequences.". Genomics 57 (1): 24–35. doi:10.1006/geno.1999.5765. PMID 10191080. 
  • Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins.". J. Cell Biol. 145 (2): 265–77. PMID 10209023. 
  • Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface.". Nat. Struct. Biol. 6 (11): 990–1. doi:10.1038/14870. PMID 10542082. 
  • Munnia A, Schütz N, Romeike BF, et al. (2001). "Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor.". Oncogene 20 (35): 4853–63. doi:10.1038/sj.onc.1204650. PMID 11521196. 
  • Rommelaere H, De Neve M, Neirynck K, et al. (2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families.". J. Biol. Chem. 276 (44): 41023–8. doi:10.1074/jbc.M106591200. PMID 11535601. 
  • Martín-Benito J, Boskovic J, Gómez-Puertas P, et al. (2003). "Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT.". EMBO J. 21 (23): 6377–86. PMID 12456645. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Bruneel A, Labas V, Mailloux A, et al. (2004). "Proteomic study of human umbilical vein endothelial cells in culture.". Proteomics 3 (5): 714–23. doi:10.1002/pmic.200300409. PMID 12748950. 
  • Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.". Science 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539. 
  • Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding.". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200. PMID 14634002. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
 This article on a gene on chromosome 5 is a stub. You can help Wikipedia by expanding it.