PEX3

From Wikipedia, the free encyclopedia

Peroxisomal biogenesis factor 3

Identifiers

PEX3; TRG18

External IDs

OMIM: 603164 MGI: 1929646 HomoloGene: 2691

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• peroxisome • integral to peroxisomal membrane • integral to plasma membrane • membrane
Biological Process:	• peroxisome organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003630 (mRNA)
NP_003621 (protein)

NM_019961 (mRNA)
NP_064345 (protein)

Location

Chr 6: 143.81 - 143.85 Mb

Chr 10: 13.21 - 13.24 Mb

Pubmed search

[1]

[2]

Peroxisomal biogenesis factor 3, also known as PEX3, is a human gene.^[1]

[edit] References

^ Entrez Gene: PEX3 peroxisomal biogenesis factor 3.

[edit] Further reading

Kammerer S, Holzinger A, Welsch U, Roscher AA (1998). "Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p.". FEBS Lett. 429 (1): 53–60. PMID 9657383.
South ST, Gould SJ (1999). "Peroxisome synthesis in the absence of preexisting peroxisomes.". J. Cell Biol. 144 (2): 255–66. PMID 9922452.
Soukupova M, Sprenger C, Gorgas K, et al. (1999). "Identification and characterization of the human peroxin PEX3.". Eur. J. Cell Biol. 78 (6): 357–74. PMID 10430017.
Muntau AC, Holzinger A, Mayerhofer PU, et al. (2000). "The human PEX3 gene encoding a peroxisomal assembly protein: genomic organization, positional mapping, and mutation analysis in candidate phenotypes.". Biochem. Biophys. Res. Commun. 268 (3): 704–10. doi:10.1006/bbrc.2000.2193. PMID 10679269.
Sacksteder KA, Jones JM, South ST, et al. (2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.". J. Cell Biol. 148 (5): 931–44. PMID 10704444.
Ghaedi K, Tamura S, Okumoto K, et al. (2000). "The peroxin pex3p initiates membrane assembly in peroxisome biogenesis.". Mol. Biol. Cell 11 (6): 2085–102. PMID 10848631.
Muntau AC, Mayerhofer PU, Paton BC, et al. (2000). "Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G.". Am. J. Hum. Genet. 67 (4): 967–75. PMID 10958759.
Ghaedi K, Honsho M, Shimozawa N, et al. (2000). "PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G.". Am. J. Hum. Genet. 67 (4): 976–81. PMID 10968777.
Fransen M, Wylin T, Brees C, et al. (2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMID 11390669.
Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.". Mol. Cell Proteomics 1 (3): 243–52. PMID 12096124.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Muntau AC, Roscher AA, Kunau WH, Dodt G (2003). "The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis.". Eur. J. Cell Biol. 82 (7): 333–42. PMID 12924628.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Muntau AC, Roscher AA, Kunau WH, Dodt G (2004). "Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET).". Adv. Exp. Med. Biol. 544: 221–4. PMID 14713233.
Fang Y, Morrell JC, Jones JM, Gould SJ (2004). "PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.". J. Cell Biol. 164 (6): 863–75. doi:10.1083/jcb.200311131. PMID 15007061.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Matsuzono Y, Matsuzaki T, Fujiki Y (2007). "Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation.". J. Cell. Sci. 119 (Pt 17): 3539–50. doi:10.1242/jcs.03100. PMID 16895967.