PEX19

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Peroxisomal biogenesis factor 19
Identifiers
Symbol(s) PEX19; D1S2223E; HK33; PMP1; PMPI; PXF; PXMP1
External IDs OMIM: 600279 MGI: 1334458 HomoloGene: 37696
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5824 19298
Ensembl ENSG00000162735 ENSMUSG00000003464
Uniprot P40855 Q3TDI5
Refseq NM_002857 (mRNA)
NP_002848 (protein)		 NM_023041 (mRNA)
NP_075528 (protein)
Location Chr 1: 158.51 - 158.52 Mb Chr 1: 173.96 - 173.97 Mb
Pubmed search [1] [2]

Peroxisomal biogenesis factor 19, also known as PEX19, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: PEX19 peroxisomal biogenesis factor 19.

[edit] Further reading

  • Braun A, Kammerer S, Weissenhorn W, et al. (1994). "Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1.". Gene 146 (2): 291–5. PMID 8076834. 
  • Kammerer S, Arnold N, Gutensohn W, et al. (1997). "Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein.". Genomics 45 (1): 200–10. doi:10.1006/geno.1997.4914. PMID 9339377. 
  • Götte K, Girzalsky W, Linkert M, et al. (1998). "Pex19p, a farnesylated protein essential for peroxisome biogenesis.". Mol. Cell. Biol. 18 (1): 616–28. PMID 9418908. 
  • Matsuzono Y, Kinoshita N, Tamura S, et al. (1999). "Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2116–21. PMID 10051604. 
  • Sacksteder KA, Jones JM, South ST, et al. (2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.". J. Cell Biol. 148 (5): 931–44. PMID 10704444. 
  • Gloeckner CJ, Mayerhofer PU, Landgraf P, et al. (2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p.". Biochem. Biophys. Res. Commun. 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. PMID 10777694. 
  • Sugihara T, Kaul SC, Kato J, et al. (2001). "Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.". J. Biol. Chem. 276 (22): 18649–52. doi:10.1074/jbc.C100011200. PMID 11259404. 
  • Fransen M, Wylin T, Brees C, et al. (2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMID 11390669. 
  • Biermanns M, Gärtner J (2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes.". Biochem. Biophys. Res. Commun. 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. PMID 11453642. 
  • Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941. 
  • Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.". Mol. Cell Proteomics 1 (3): 243–52. PMID 12096124. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ito M, Iidawa S, Izuka M, et al. (2004). "Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate.". Biochem. J. 377 (Pt 3): 607–16. doi:10.1042/BJ20031223. PMID 14558883. 
  • Jones JM, Morrell JC, Gould SJ (2004). "PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.". J. Cell Biol. 164 (1): 57–67. doi:10.1083/jcb.200304111. PMID 14709540. 
  • Muntau AC, Roscher AA, Kunau WH, Dodt G (2004). "Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET).". Adv. Exp. Med. Biol. 544: 221–4. PMID 14713233. 
  • Fransen M, Vastiau I, Brees C, et al. (2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes.". J. Biol. Chem. 279 (13): 12615–24. doi:10.1074/jbc.M304941200. PMID 14715663. 
  • Fang Y, Morrell JC, Jones JM, Gould SJ (2004). "PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.". J. Cell Biol. 164 (6): 863–75. doi:10.1083/jcb.200311131. PMID 15007061. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Shibata H, Kashiwayama Y, Imanaka T, Kato H (2004). "Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins.". J. Biol. Chem. 279 (37): 38486–94. doi:10.1074/jbc.M402204200. PMID 15252024. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
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