PEX14

From Wikipedia, the free encyclopedia

Peroxisomal biogenesis factor 14

Identifiers

PEX14; MGC12767; NAPP2; Pex14p; dJ734G22.2

External IDs

OMIM: 601791 MGI: 1927868 HomoloGene: 37936

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• peroxisome • integral to peroxisomal membrane • membrane
Biological Process:	• protein targeting • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004565 (mRNA)
NP_004556 (protein)

XM_622907 (mRNA)
XP_622907 (protein)

Location

Chr 1: 10.46 - 10.61 Mb

Chr 4: 147.8 - 147.94 Mb

Pubmed search

[1]

[2]

Peroxisomal biogenesis factor 14, also known as PEX14, is a human gene.^[1]

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.^[1]

[edit] References

^ ^a ^b Entrez Gene: PEX14 peroxisomal biogenesis factor 14.

[edit] Further reading

Albertini M, Rehling P, Erdmann R, et al. (1997). "Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways.". Cell 89 (1): 83–92. PMID 9094717.
Huhse B, Rehling P, Albertini M, et al. (1998). "Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery.". J. Cell Biol. 140 (1): 49–60. PMID 9425153.
Fransen M, Terlecky SR, Subramani S (1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8087–92. PMID 9653144.
Will GK, Soukupova M, Hong X, et al. (1999). "Identification and characterization of the human orthologue of yeast Pex14p.". Mol. Cell. Biol. 19 (3): 2265–77. PMID 10022913.
Girzalsky W, Rehling P, Stein K, et al. (1999). "Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes.". J. Cell Biol. 144 (6): 1151–62. PMID 10087260.
Shimizu N, Itoh R, Hirono Y, et al. (1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis.". J. Biol. Chem. 274 (18): 12593–604. PMID 10212238.
Sacksteder KA, Jones JM, South ST, et al. (2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.". J. Cell Biol. 148 (5): 931–44. PMID 10704444.
Gavva NR, Wen SC, Daftari P, et al. (2002). "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor.". Genomics 79 (3): 423–31. doi:10.1006/geno.2002.6714. PMID 11863372.
Otera H, Setoguchi K, Hamasaki M, et al. (2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import.". Mol. Cell. Biol. 22 (6): 1639–55. PMID 11865044.
Alland L, David G, Shen-Li H, et al. (2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.". Mol. Cell. Biol. 22 (8): 2743–50. PMID 11909966.
Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.". Mol. Cell Proteomics 1 (3): 243–52. PMID 12096124.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Oliveira ME, Reguenga C, Gouveia AM, et al. (2003). "Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction.". Biochim. Biophys. Acta 1567 (1-2): 13–22. PMID 12488033.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Fransen M, Vastiau I, Brees C, et al. (2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes.". J. Biol. Chem. 279 (13): 12615–24. doi:10.1074/jbc.M304941200. PMID 14715663.
Shimozawa N, Tsukamoto T, Nagase T, et al. (2004). "Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene.". Hum. Mutat. 23 (6): 552–8. doi:10.1002/humu.20032. PMID 15146459.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Nguyen T, Bjorkman J, Paton BC, Crane DI (2006). "Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance.". J. Cell. Sci. 119 (Pt 4): 636–45. doi:10.1242/jcs.02776. PMID 16449325.