PEX13

From Wikipedia, the free encyclopedia

Peroxisome biogenesis factor 13

PDB rendering based on 1wxu.

Available structures: 1wxu

Identifiers

Symbol(s)

PEX13; NALD; ZWS

External IDs

OMIM: 601789 MGI: 1919379 HomoloGene: 1967

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane fraction • peroxisome • integral to peroxisomal membrane • membrane • integral to membrane
Biological Process:	• protein transport • protein import into peroxisome matrix, docking

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002618 (mRNA)
NP_002609 (protein)

NM_023651 (mRNA)
NP_076140 (protein)

Location

Chr 2: 61.1 - 61.13 Mb

Chr 11: 23.55 - 23.57 Mb

Pubmed search

[1]

[2]

Peroxisome biogenesis factor 13, also known as PEX13, is a human gene.^[1]

[edit] References

^ Entrez Gene: PEX13 peroxisome biogenesis factor 13.

[edit] Further reading

Gould SJ, Kalish JE, Morrell JC, et al. (1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor.". J. Cell Biol. 135 (1): 85-95. PMID 8858165.
Albertini M, Rehling P, Erdmann R, et al. (1997). "Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways.". Cell 89 (1): 83-92. PMID 9094717.
Fransen M, Terlecky SR, Subramani S (1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8087-92. PMID 9653144.
Björkman J, Stetten G, Moore CS, et al. (1999). "Genomic structure of PEX13, a candidate peroxisome biogenesis disorder gene.". Genomics 54 (3): 521-8. doi:10.1006/geno.1998.5520. PMID 9878256.
Girzalsky W, Rehling P, Stein K, et al. (1999). "Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes.". J. Cell Biol. 144 (6): 1151-62. PMID 10087260.
Shimozawa N, Suzuki Y, Zhang Z, et al. (1999). "Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders.". Hum. Mol. Genet. 8 (6): 1077-83. PMID 10332040.
Toyama R, Mukai S, Itagaki A, et al. (2000). "Isolation, characterization and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants.". Hum. Mol. Genet. 8 (9): 1673-81. PMID 10441330.
Liu Y, Björkman J, Urquhart A, et al. (1999). "PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders.". Am. J. Hum. Genet. 65 (3): 621-34. PMID 10441568.
Sacksteder KA, Jones JM, South ST, et al. (2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.". J. Cell Biol. 148 (5): 931-44. PMID 10704444.
Fransen M, Wylin T, Brees C, et al. (2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.". Mol. Cell. Biol. 21 (13): 4413-24. doi:10.1128/MCB.21.13.4413-4424.2001. PMID 11390669.
Jones JM, Morrell JC, Gould SJ (2001). "Multiple distinct targeting signals in integral peroxisomal membrane proteins.". J. Cell Biol. 153 (6): 1141-50. PMID 11402059.
Otera H, Setoguchi K, Hamasaki M, et al. (2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import.". Mol. Cell. Biol. 22 (6): 1639-55. PMID 11865044.
Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.". Mol. Cell Proteomics 1 (3): 243-52. PMID 12096124.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fransen M, Vastiau I, Brees C, et al. (2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes.". J. Biol. Chem. 279 (13): 12615-24. doi:10.1074/jbc.M304941200. PMID 14715663.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hashimoto K, Kato Z, Nagase T, et al. (2005). "Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder.". Pediatr. Res. 58 (2): 263-9. doi:10.1203/01.PDR.0000169984.89199.69. PMID 16006427.
Nguyen T, Bjorkman J, Paton BC, Crane DI (2006). "Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance.". J. Cell. Sci. 119 (Pt 4): 636-45. doi:10.1242/jcs.02776. PMID 16449325.