Peptide-tryptophan 2,3-dioxygenase

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In enzymology, a peptide-tryptophan 2,3-dioxygenase (EC 1.13.11.26) is an enzyme that catalyzes the chemical reaction

peptide tryptophan + O₂ peptide formylkynurenine

Thus, the two substrates of this enzyme are peptide tryptophan and O₂, whereas its product is peptide formylkynurenine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Other names in common use include pyrrolooxygenase, peptidyltryptophan 2,3-dioxygenase, and tryptophan pyrrolooxygenase.

[edit] References

• IUBMB entry for 1.13.11.26
• BRENDA references for 1.13.11.26 (Recommended.)
• PubMed references for 1.13.11.26
• PubMed Central references for 1.13.11.26
• Google Scholar references for 1.13.11.26
• Frydman RB, Tomaro ML, Frydman B (1972). "Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides". Biochim. Biophys. Acta. 284: 80–9. PMID 4403729. 

[edit] External links

The CAS registry number for this enzyme class is 37256-64-7.

• IUBMB entry for 1.13.11.26

• KEGG entry for 1.13.11.26

• BRENDA entry for 1.13.11.26

• NiceZyme view of 1.13.11.26

• EC2PDB: PDB structures for 1.13.11.26

• PRIAM entry for 1.13.11.26

• PUMA2 entry for 1.13.11.26

• IntEnz: Integrated Enzyme entry for 1.13.11.26

• MetaCyc entry for 1.13.11.26

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050169: peptide-tryptophan 2,3-dioxygenase

• AMIGO entry for GO code 0050169: peptide-tryptophan 2,3-dioxygenase