Pentalenene synthase

From Wikipedia, the free encyclopedia

In enzymology, a pentalenene synthase (EC 4.2.3.7) is an enzyme that catalyzes the chemical reaction

2-trans,6-trans-farnesyl diphosphate pentalenene + diphosphate

Hence, this enzyme has one substrate, 2-trans,6-trans-farnesyl diphosphate, and two products, pentalenene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming). This enzyme is also called pentalenene synthetase.

[edit] References

• IUBMB entry for 4.2.3.7
• BRENDA references for 4.2.3.7 (Recommended.)
• PubMed references for 4.2.3.7
• PubMed Central references for 4.2.3.7
• Google Scholar references for 4.2.3.7
• Cane DE (1983). "Cell-free studies of monoterpene and sesquiterpene biosynthesis". Biochem. Soc. Trans. 11: 510–5. PMID 6642060. 
• Cane DE and Tillman AM (1983). "Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate". J. Am. Chem. Soc. 105: 122–124. doi:10.1021/ja00339a026. 
• JS, Hubbard BR (1994). "Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319". Biochemistry. 33: 5846–57. doi:10.1021/bi00185a024. PMID 8180213. 

[edit] External links

The CAS registry number for this enzyme class is 90597-46-9.

• IUBMB entry for 4.2.3.7

• KEGG entry for 4.2.3.7

• BRENDA entry for 4.2.3.7

• NiceZyme view of 4.2.3.7

• EC2PDB: PDB structures for 4.2.3.7

• PRIAM entry for 4.2.3.7

• PUMA2 entry for 4.2.3.7

• IntEnz: Integrated Enzyme entry for 4.2.3.7

• MetaCyc entry for 4.2.3.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050467: pentalenene synthase

• AMIGO entry for GO code 0050467: pentalenene synthase