PEG3

From Wikipedia, the free encyclopedia

Paternally expressed 3

Identifiers

PEG3; DKFZp781A095; KIAA0287; PW1; ZSCAN24

External IDs

OMIM: 601483 MGI: 104748 HomoloGene: 31363

Gene ontology
Molecular Function:	• nucleic acid binding • transcription factor activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• regulation of transcription, DNA-dependent • apoptosis

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006210 (mRNA)
NP_006201 (protein)

NM_001010988 (mRNA)
NP_001010988 (protein)

Location

n/a

Chr 7: 6.31 - 6.33 Mb

Pubmed search

[1]

[2]

Paternally expressed 3, also known as PEG3, is a human gene.^[1]

[edit] References

^ Entrez Gene: PEG3 paternally expressed 3.

[edit] Further reading

Kim J, Ashworth L, Branscomb E, Stubbs L (1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4.". Genome Res. 7 (5): 532–40. PMID 9149948.
Relaix F, Wei XJ, Wu X, Sassoon DA (1998). "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway.". Nat. Genet. 18 (3): 287–91. doi:10.1038/ng0398-287. PMID 9500555.
Relaix F, Wei X, Li W, et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. doi:10.1073/pnas.040378897. PMID 10681424.
Kim J, Bergmann A, Stubbs L (2000). "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3).". Genomics 64 (1): 114–8. doi:10.1006/geno.1999.6112. PMID 10708526.
Kohda T, Asai A, Kuroiwa Y, et al. (2001). "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line.". Genes Cells 6 (3): 237–47. PMID 11260267.
Hiby SE, Lough M, Keverne EB, et al. (2001). "Paternal monoallelic expression of PEG3 in the human placenta.". Hum. Mol. Genet. 10 (10): 1093–100. PMID 11331620.
Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening.". J. Cell. Biochem. 83 (4): 521–31. PMID 11746496.
Johnson MD, Wu X, Aithmitti N, Morrison RS (2002). "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death.". J. Biol. Chem. 277 (25): 23000–7. doi:10.1074/jbc.M201907200. PMID 11943780.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Mirey G, Chartrain I, Froment C, et al. (2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis.". Cell Cycle 4 (6): 806–11. PMID 15908796.
Dowdy SC, Gostout BS, Shridhar V, et al. (2005). "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines.". Gynecol. Oncol. 99 (1): 126–34. doi:10.1016/j.ygyno.2005.05.036. PMID 16023706.
Chartrain I, Couturier A, Tassan JP (2006). "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells.". Biol. Cell 98 (4): 253–63. doi:10.1042/BC20050041. PMID 16159311.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.