PEG10

From Wikipedia, the free encyclopedia

Paternally expressed 10

Identifiers

PEG10; Edr; HB-1; KIAA1051; MEF3L; Mar2; Mart2; RGAG3

External IDs

OMIM: 609810 MGI: 2157785 HomoloGene: 9009

Gene ontology
Molecular Function:	• nucleic acid binding • protein binding • zinc ion binding
Cellular Component:	• cytoplasm
Biological Process:	• negative regulation of transforming growth factor beta receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001040152 (mRNA)
NP_001035242 (protein)

NM_001040611 (mRNA)
NP_001035701 (protein)

Location

Chr 7: 94.12 - 94.14 Mb

n/a

Pubmed search

[1]

[2]

Paternally expressed 10, also known as PEG10, is a human gene.^[1]

This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.^[1]

[edit] References

^ ^a ^b Entrez Gene: PEG10 paternally expressed 10.

[edit] Further reading

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Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
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Volff J, Körting C, Schartl M (2001). "Ty3/Gypsy retrotransposon fossils in mammalian genomes: did they evolve into new cellular functions?". Mol. Biol. Evol. 18 (2): 266–70. PMID 11158386.
Ono R, Kobayashi S, Wagatsuma H, et al. (2001). "A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21.". Genomics 73 (2): 232–7. doi:10.1006/geno.2001.6494. PMID 11318613.
Shigemoto K, Brennan J, Walls E, et al. (2001). "Identification and characterisation of a developmentally regulated mammalian gene that utilises -1 programmed ribosomal frameshifting.". Nucleic Acids Res. 29 (19): 4079–88. PMID 11574691.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Smallwood A, Papageorghiou A, Nicolaides K, et al. (2004). "Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta.". Biol. Reprod. 69 (1): 286–93. doi:10.1095/biolreprod.102.013078. PMID 12620933.
Okabe H, Satoh S, Furukawa Y, et al. (2003). "Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.". Cancer Res. 63 (12): 3043–8. PMID 12810624.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Tsou AP, Chuang YC, Su JY, et al. (2004). "Overexpression of a novel imprinted gene, PEG10, in human hepatocellular carcinoma and in regenerating mouse livers.". J. Biomed. Sci. 10 (6 Pt 1): 625–35. doi:10.1159/000073528. PMID 14576465.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Lux A, Beil C, Majety M, et al. (2005). "Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.". J. Biol. Chem. 280 (9): 8482–93. doi:10.1074/jbc.M409197200. PMID 15611116.
Brandt J, Schrauth S, Veith AM, et al. (2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals.". Gene 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091.
Manktelow E, Shigemoto K, Brierley I (2005). "Characterization of the frameshift signal of Edr, a mammalian example of programmed -1 ribosomal frameshifting.". Nucleic Acids Res. 33 (5): 1553–63. doi:10.1093/nar/gki299. PMID 15767280.
He H, Olesnanik K, Nagy R, et al. (2005). "Allelic variation in gene expression in thyroid tissue.". Thyroid 15 (7): 660–7. doi:10.1089/thy.2005.15.660. PMID 16053381.
Brandt J, Veith AM, Volff JN (2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes.". Cytogenet. Genome Res. 110 (1-4): 307–17. doi:10.1159/000084963. PMID 16093683.
Hu C, Xiong J, Zhang L, et al. (2006). "PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia.". Cell. Mol. Immunol. 1 (4): 280–94. PMID 16225771.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Li CM, Margolin AA, Salas M, et al. (2006). "PEG10 is a c-MYC target gene in cancer cells.". Cancer Res. 66 (2): 665–72. doi:10.1158/0008-5472.CAN-05-1553. PMID 16423995.