PDZD2

From Wikipedia, the free encyclopedia

PDZ domain containing 2

Identifiers

PDZD2; PIN1; AIPC; KIAA0300; PAPIN; PDZK3

External IDs

OMIM: 610697 MGI: 1922394 HomoloGene: 23393

Gene ontology
Molecular Function:	• structural molecule activity • protein binding
Cellular Component:	• extracellular region • nucleus • cytoplasm • endoplasmic reticulum • intercellular junction
Biological Process:	• cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_178140 (mRNA)
NP_835260 (protein)

XM_127972 (mRNA)
XP_127972 (protein)

Location

Chr 5: 31.68 - 32.15 Mb

Chr 15: 12.31 - 12.54 Mb

Pubmed search

[1]

[2]

PDZ domain containing 2, also known as PDZD2, is a human gene.^[1]

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: PDZD2 PDZ domain containing 2.

[edit] Further reading

Lindahl P, Abrahamson M, Björk I (1992). "Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin.". Biochem. J. 281 ( Pt 1): 49-55. PMID 1731767.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141-50. PMID 9205841.
Deguchi M, Iizuka T, Hata Y, et al. (2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071.". J. Biol. Chem. 275 (38): 29875-80. doi:10.1074/jbc.M005384200. PMID 10896674.
Chaib H, Rubin MA, Mucci NR, et al. (2001). "Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors.". Cancer Res. 61 (6): 2390-4. PMID 11289102.
Ohno H, Hirabayashi S, Iizuka T, et al. (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells.". Oncogene 21 (46): 7042-9. doi:10.1038/sj.onc.1205852. PMID 12370826.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yeung ML, Tam TS, Tsang AC, Yao KM (2003). "Proteolytic cleavage of PDZD2 generates a secreted peptide containing two PDZ domains.". EMBO Rep. 4 (4): 412-8. doi:10.1038/sj.embor.embor804. PMID 12671685.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Ma RY, Tam TS, Suen AP, et al. (2006). "Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells.". Int. J. Biochem. Cell Biol. 38 (5-6): 1015-22. doi:10.1016/j.biocel.2005.11.012. PMID 16413998.