PDXK

From Wikipedia, the free encyclopedia

Pyridoxal (pyridoxine, vitamin B6) kinase

PDB rendering based on 2ajp.

Available structures: 2ajp, 2f7k

Identifiers

Symbol(s)

PDXK; C21orf97; PKH; PNK

External IDs

OMIM: 179020 MGI: 1351869 HomoloGene: 2731

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding • zinc ion binding • pyridoxal kinase activity • transferase activity • metal ion binding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003681 (mRNA)
NP_003672 (protein)

NM_172134 (mRNA)
NP_742146 (protein)

Location

Chr 21: 43.96 - 44.01 Mb

Chr 10: 77.84 - 77.87 Mb

Pubmed search

[1]

[2]

Pyridoxal (pyridoxine, vitamin B6) kinase, also known as PDXK, is a human gene.^[1]

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: PDXK pyridoxal (pyridoxine, vitamin B6) kinase.

[edit] Further reading

Chern CJ, Beutler E (1976). "Biochemical and electrophoretic studies of erythrocyte pyridoxine kinase in white and black Americans.". Am. J. Hum. Genet. 28 (01): 9–17. PMID 2009.
Merrill AH, Henderson JM, Wang E, et al. (1984). "Metabolism of vitamin B-6 by human liver.". J. Nutr. 114 (9): 1664–74. PMID 6088736.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Zhang Z, Smith E, Surowiec SM, et al. (1993). "Synthesis of N-(4'-pyridoxyl)sphingosine and its uptake and metabolism by isolated cells.". Membrane biochemistry 10 (1): 53–9. PMID 8510562.
Hanna MC, Turner AJ, Kirkness EF (1997). "Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor.". J. Biol. Chem. 272 (16): 10756–60. PMID 9099727.
Lainé-Cessac P, Cailleux A, Allain P (1997). "Mechanisms of the inhibition of human erythrocyte pyridoxal kinase by drugs.". Biochem. Pharmacol. 54 (8): 863–70. PMID 9354586.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Lee HS, Moon BJ, Choi SY, Kwon OS (2001). "Human pyridoxal kinase: overexpression and properties of the recombinant enzyme.". Mol. Cells 10 (4): 452–9. PMID 10987144.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Shin JH, Weitzdoerfer R, Fountoulakis M, Lubec G (2004). "Expression of cystathionine beta-synthase, pyridoxal kinase, and ES1 protein homolog (mitochondrial precursor) in fetal Down syndrome brain.". Neurochem. Int. 45 (1): 73–9. doi:10.1016/j.neuint.2003.12.004. PMID 15082224.
Fang X, Zhou ZM, Lu L, et al. (2004). "Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis.". Asian J. Androl. 6 (2): 83–91. PMID 15154080.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary.". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Flanagan JM, Beutler E (2006). "The genetic basis of human erythrocyte pyridoxal kinase activity variation.". Haematologica 91 (6): 801–4. PMID 16704963.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.". BMC Genomics 7: 155. doi:10.1186/1471-2164-7-155. PMID 16780588.
Musayev FN, di Salvo ML, Ko TP, et al. (2007). "Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation.". Protein Sci. 16 (10): 2184–94. doi:10.1110/ps.073022107. PMID 17766369.